SLU-11695
SLU-11695 is an orally active antiparasitic agent belonging to the pyrazolo[3,4-d]pyrimidine benzoxaborole class. SLU-11695 inhibits the asexual reproduction of Cryptosporidium parvum, eliminates parasite shedding, and prevents post-exposure recurrence. SLU-11695 can be used in the research of cryptosporidiosis.
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- CAS No.: 3065121-95-8
- Formule: C23H23BFN5O2
- Masse moléculaire:431.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | EC50 |
0.025 μM
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Inhibition of Cryptosporidium parvum growth in human colon carcinoma HCT-8 cell monolayers infected with C. parvum (Iowa strain) oocysts, assessed via automated fluorescence microscopy after 48 h incubation with the compound following a 3-hour invasion period.
Inhibition of Cryptosporidium parvum growth in human colon carcinoma HCT-8 cell monolayers infected with C. parvum (Iowa strain) oocysts, assessed via automated fluorescence microscopy after 48 h incubation with the compound following a 3-hour invasion period.
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42593902 |
| HCT-8 | CC50 |
~77 μM
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Host cell cytotoxicity against human colon carcinoma HCT-8 cells, assessed during the Cryptosporidium parvum growth inhibition assay after 48 h incubation with the compound.
Host cell cytotoxicity against human colon carcinoma HCT-8 cells, assessed during the Cryptosporidium parvum growth inhibition assay after 48 h incubation with the compound.
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42593902 |
In Vitro
SLU-11695 (0.025 μM; 48 h) potently inhibits Cryptosporidium parvum growth in HCT-8 cells with an EC50 of 0.025 μM and exhibits >3000-fold selectivity over host cell cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) (male, 4-5 weeks old)[1]
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Dosage:50 mg/kg
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Administration:p.o.; twice daily; 4 days
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Result:Eliminated *C. parvum* fecal shedding with no evidence of relapse up to 8 days after dosing cessation.
Showed no apparent side effects in all tested mice.
Chemical Information
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CAS No. 3065121-95-8
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Masse moléculaire 431.27
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Formule C23H23BFN5O2
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SMILES
CCC1=NN(C)C2=NC(C3=CC=C(B(O)OC4C)C4=C3)=NC(NCC5=CC=C(F)C=C5)=C21
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SLU-11695 Related Classifications
HY-189004 Related Classifications
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