CQ211

Name: CQ211
Brand: MedChemExpress
SKU: HY-147655
Rating: 5.0 (0 reviews)

Cat. No.: HY-147655 Pureza: 99.90%: Ficha de datos
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CQ211 is a potent and selective RIOK2 inhibitor with a K_d of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines.

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CQ211 Estructura química

No. CAS : 2648986-65-4

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	En stock	Estimated Time of Arrival: December 31
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Descripciòn

CQ211 is a potent and selective RIOK2 inhibitor with a K_d of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines^[1].

IC₅₀ & Target

RIOK2

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	0.38 μM Compound: 7m ; CQ211	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay	[PMID: 35584513]
MKN-1	IC₅₀	0.61 μM Compound: 7m ; CQ211	Antiproliferative activity against human MKN-1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MKN-1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay	[PMID: 35584513]
MKN-1	IC₅₀	1.69 μM Compound: 7; CQ211	Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 37859717]
MOLT-4	IC₅₀	2.12 μM Compound: 7; CQ211	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 37859717]
U-87MG ATCC	IC₅₀	1.65 μM Compound: 7; CQ211	Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 37859717]

In Vitro

CQ211 (0-5.0 μM; 4 h) suppresses the phosphorylation of mTOR in cancer cells^[1].
CQ211 can obviously suppress the proliferation of MKN-1 and HT-29 cells with IC₅₀ values of 0.61 μM and 0.38 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	MKN-1 and HT-29 cells
Concentration:	0, 0.3, 0.6, 1.2, 2.5, and 5.0 μM
Incubation Time:	4 h
Result:	Suppresseed the phosphorylation of mTOR in cancer cells.

In Vivo

CQ211 (25 mg/kg; i.p; for 18 consecutive days; once daily) inhibits MKN-1 xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female CB17-SCID mice (6-8 weeks of age) injected wtih MKN-1 cells^[1]
Dosage:	25 mg/kg
Administration:	Intraperitoneal administration; for 18 consecutive days; once daily
Result:	Inhibited the tumor progression with tumor growth inhibition (TGI) of 30.9%.

Peso molecular

521.49

Fòrmula

C₂₆H₂₂F₃N₇O₂

No. CAS

2648986-65-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C2=C(C3=CC(C4=CC=C(N=C4)OC)=CC=C3N1)N(N=N2)C5=CC=C(C(C(F)(F)F)=C5)N6CCNCC6

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvente y solubilidad

In Vitro:

DMSO : 12.5 mg/mL (23.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9176 mL	9.5879 mL	19.1758 mL
5 mM	0.3835 mL	1.9176 mL	3.8352 mL
10 mM	0.1918 mL	0.9588 mL	1.9176 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.90%

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Ficha de datos (284 KB) SDS (252 KB)

COA (264 KB) HNMR (284 KB) RP-HPLC (222 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Ouyang Y, et al. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65(11):7833-7842. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9176 mL	9.5879 mL	19.1758 mL	47.9396 mL
	5 mM	0.3835 mL	1.9176 mL	3.8352 mL	9.5879 mL
	10 mM	0.1918 mL	0.9588 mL	1.9176 mL	4.7940 mL
	15 mM	0.1278 mL	0.6392 mL	1.2784 mL	3.1960 mL
	20 mM	0.0959 mL	0.4794 mL	0.9588 mL	2.3970 mL

CQ211 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CQ2112648986-65-4CQ 211CQ-211RIO KinaseRright open reading frame KinaseantitumorMKN-1HT-29Inhibitorinhibitorinhibit

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CQ211

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Complete Stock Solution Preparation Table

CQ211 Related Classifications

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