Crobenetine  (Synonyms: BIII-890; BIII-890 CL free acid)

Crobenetine (BIII-890), a benzomorphan derivative, is a potent, selective, and highly use-dependent Na⁺ channel blocker. Crobenetine displaces ^[3H]BTX from site 2 of the Na⁺ channel (IC₅₀=49 nM) in rat brain synaptosomes, yet exhibits only low binding affinity for other receptors and ion channels. Crobenetine protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents^[1].

Crobenetine (BIII-890; BIII 890 CL; 3-30 mg/kg; s.c.) reduces lesion size in mice and rats when administered 5 min after permanent focal cerebral ischemia at doses that does not impair motor coordination^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

379.54

C₂₅H₃₃NO₂

221019-25-6

OC1=C2C([C@]3(C)CCN(C[C@@H](OCC4=CC=CC=C4)C)[C@](C3(C)C)([H])C2)=CC=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. A J Carter, et al. Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4944-9.  [Content Brief]