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Cat. No.: HY-N21736

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Cucurbitacin K 2-O-β-D-glucopyranoside

Cucurbitacin K 2-O-β-D-glucopyranoside is a cucurbitacin glycoside. Cucurbitacin K 2-O-β-D-glucopyranoside is isolated from the fruits of Citrullus colocynthis, the roots of Machilus yaoshansis, and the fruits of Cucurbita pepo cv dayangua.

For research use only. We do not sell to patients.

CAS No.: 415711-05-6
Formula: C₃₆H₅₄O₁₃
Molecular Weight:694.82

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Please store the product under the recommended conditions in the Certificate of Analysis.

Cucurbitacin K 2-O-β-D-glucopyranoside Chemical Structure

CAS No.: 415711-05-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Cellular Effect
- In Vitro
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC50	>10 μM	Cytotoxicity against human A2780 ovary cancer cells assessed as inhibition of cell proliferation. Cytotoxicity against human A2780 ovary cancer cells assessed as inhibition of cell proliferation.	22044245
HCT-8	IC50	>10 μM	Cytotoxicity against human HCT-8 colon cancer cells assessed as inhibition of cell proliferation. Cytotoxicity against human HCT-8 colon cancer cells assessed as inhibition of cell proliferation.	22044245
Bel-7402	IC50	>10 μM	Cytotoxicity against human Bel-7402 hepatoma cancer cells assessed as inhibition of cell proliferation. Cytotoxicity against human Bel-7402 hepatoma cancer cells assessed as inhibition of cell proliferation.	22044245
BGC-823	IC50	>10 μM	Cytotoxicity against human BGC-823 stomach cancer cells assessed as inhibition of cell proliferation. Cytotoxicity against human BGC-823 stomach cancer cells assessed as inhibition of cell proliferation.	22044245
A549	IC50	>10 μM	Cytotoxicity against human A549 lung cancer cells assessed as inhibition of cell proliferation. Cytotoxicity against human A549 lung cancer cells assessed as inhibition of cell proliferation.	22044245

In Vitro

Cucurbitacin K 2-O-β-D-glucopyranoside is inactive against A2780, HCT-8, Bel-7402, BGC-823, and A549 cancer cell lines with IC₅₀ values greater than 10 μM^[2].
Cucurbitacin K 2-O-β-D-glucopyranoside (10 μM) does not inhibit TNF-α secretion from mouse peritoneal macrophages at 10 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 415711-05-6
Molecular Weight 694.82
Formula C₃₆H₅₄O₁₃
SMILES

C[C@]12[C@]3([C@](C)([C@]4(C(=CC3)C(C)(C)C(=O)C(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)=C4)[H])C(=O)C[C@]1(C)[C@@]([C@@](C(C[C@H](C(C)(C)O)O)=O)(C)O)([C@H](O)C2)[H])[H]
Structure Classification
- Terpenoids
- Tetracyclic Triterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Akanji OC, et al. Evaluation of laxative activity of aqueous extract of Citrullus colocynthis (L.) Schrad. fruits on mice.

[2]. Gan M, et al. Cucurbitane glucosides from the root of Machilus yaoshansis. Journal of natural products. 2011 Nov 28;74(11):2431-7. [Content Brief]

[3]. Wang DC, et al. Cucurbitane and hexanorcucurbitane glycosides from the fruits of Cucurbita pepo cv dayangua. Journal of Asian natural products research. 2007 Sep 1;9(6):525-9.

[4]. Kapoor M, et al. Citrullus colocynthis an important plant in indian traditional system of medicine. Pharmacognosy Reviews. 2020 Jan 1;14(27):22.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cucurbitacin K 2-O-β-D-glucopyranoside

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Cucurbitacin K 2-O-β-D-glucopyranoside

Biological Activity

Description

Cellular Effect

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cucurbitacin K 2-O-β-D-glucopyranoside Related Classifications

HY-N21736 Related Classifications

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