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製品番号: HY-P11912

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Cyclo(Val-Val-Ile-d-Ala-Trp(Bodipy)-Gly)

Cyclo (Val-Val-Ile-d-Ala-Trp (Bodipy)-Gly) is a cyclic peptide-BODIPY conjugate. Cyclo (Val-Val-Ile-d-Ala-Trp (Bodipy)-Gly) detects prefibrillar Aβ_1-42 aggregates in neuronal cells, generating perinuclear punctate fluorescent spots. Cyclo (Val-Val-Ile-d-Ala-Trp (Bodipy)-Gly) is applicable to Alzheimer's disease-related research.

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分子式: C₅₇H₇₂BF₂N₉O₆
分子量:1028.05

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

Cyclo(Val-Val-Ile-d-Ala-Trp(Bodipy)-Gly) 構造式

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Cyclo (Val-Val-Ile-d-Ala-Trp (Bodipy)-Gly) efficiently detects early fibril-precursor Aβ_1-42 oligomers in cell-free aggregation assays. Its fluorescence enhancement effect outperforms that of taBODIPY under both pH 7.4 and pH 8.0 aggregation conditions. In addition, it shows high selectivity for Aβ_1-42 oligomers but low selectivity for IAPP oligomers^[1].
Cyclo (Val-Val-Ile-d-Ala-Trp (Bodipy)-Gly) binds to monomeric Aβ_1-42, and its apparent K_d value is determined to be 0.07 μM by fluorescence spectroscopy titration^[1].
Cyclo (Val-Val-Ile-d-Ala-Trp (Bodipy)-Gly) (10 μM; 2 h) effectively detects intracellular Aβ_1-42 aggregates in SH-SY5Y cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

SH-SY5Y human neuroblastoma cells
Concentration:

10 μM
Incubation Time:

2 h
Result:

Produced distinct punctate fluorescent spots localized intracellularly, concentrated around the perinuclear region, indicating detection of aggregated Aβ_1-42 species.
Produced clearer, more localized signals than conventional D54 and OC antibodies, which showed weak, diffuse cytoplasmic signals with no well-defined puncta.

化学情報

分子量 1028.05
分子式 C₅₇H₇₂BF₂N₉O₆
配列

Cyclo(Val-Val-Ile-{d-Ala-Trp(Bodipy)}-Gly)
シーケンスの短縮

Cyclo(VVI-{d-Ala-Trp(Bodipy)}-G)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Panek S, et al. Cyclopeptide-Based Fluorescent Conjugates for Monitoring Prefibrillar Aβ Nanostructures. Journal of medicinal chemistry. 2026 Mar 26;69(6):7377-7392.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Cyclo(Val-Val-Ile-d-Ala-Trp(Bodipy)-Gly)

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Cyclo(Val-Val-Ile-d-Ala-Trp(Bodipy)-Gly)

生物活性

製品説明

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Cyclo(Val-Val-Ile-d-Ala-Trp(Bodipy)-Gly) 関連分類

HY-P11912 関連分類

Bioz

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