1. Cytokines
  2. Recombinant Human Betacellulin

Recombinant Human Betacellulin

Cat. No.: HY-P7005
Handling Instructions

Recombinant Human Betacellulin is a glycoprotein, improves glucose tolerance by promoting β-cell differentiation and regeneration from ductal and/or acinar cells.

For research use only. We do not sell to patients.

Cytokines-MedChemExpress
Size Price Stock
10 μg $140 Get quote
50 μg $420 Get quote

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  • Technical Parameters

  • Properties

  • Description

Synonyms
rHuBetacellulin; Probetacellulin; BTC
Species

Human

Source

E. coli

Accession

P35070

Gene ID

685

Molecular Weight

Approximately 15 kDa

AA Sequence

MDGNSTRSPE TNGLLCGDPE ENCAATTTQS KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF Y

Biological Activity
The ED50 is <0.01 ng/mL as measured by murine Balb/3T3 cells, corresponding to a specific activity of >1.0 × 108 units/mg.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS

Endotoxin Level

<0.2 EU/μg, determined by LAL method.

Reconsititution

Reconstitute the lyophilized recombinant Human Betacellulin (rHuBetacellulin) to 100 μg/mL using ddH2O or PBS.

Storage & Stability

Lyophilized recombinant Human Betacellulin (rHuBetacellulin) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

Betacellulin (BTC), a member of the epidermal growth factor family, is expressed predominantly in the human pancreas and induces the differentiation of a pancreatic acinar cell line (AR42J) into insulin-secreting cells. Betacellulin binds and activates the EGF receptor (EGFR/erbB-1) and erbB-4, and it induces tyrosine phosphorylation of erbB-2, which couples with the EGFR or erbB-4[1].

References
  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Recombinant Human Betacellulin
Cat. No.:
HY-P7005
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