DBCO-NHCO-S-S-NHS ester

Name: DBCO-NHCO-S-S-NHS ester
Brand: MedChemExpress
SKU: HY-133412
Rating: 4.5 (0 reviews)

Cat. No.: HY-133412 Pureza: 96.02%: Ficha de datos
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DBCO-NHCO-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHCO-S-S-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-NHCO-S-S-NHS ester Estructura química

No. CAS : 2749932-04-3

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
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100 mg	Obtener un presupuesto

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Based on 1 Customer Validation

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•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas ADC Linker:

Ver todas las isoformas

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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Descripciòn

DBCO-NHCO-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. DBCO-NHCO-S-S-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

Disulfide Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

565.66

Fòrmula

C₂₈H₂₇N₃O₆S₂

No. CAS

2749932-04-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCNC(CCSSCCC(ON4C(CCC4=O)=O)=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Purity: 96.02%

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Ficha de datos (267 KB) SDS (393 KB)

COA (247 KB) HNMR (307 KB) LCMS (101 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]