2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. DCLK1-IN-2

DCLK1-IN-2 (compound I-5) is a potent DCLK1 inhibitor with an IC50 of 171.3  nM. DCLK1-IN-2 shows remarkable antiproliferative effects on SW1990 cell lines (IC50 of 0.6 μM) and in vivo antitumor potency.

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DCLK1-IN-2

DCLK1-IN-2 Chemische Struktur

CAS. Nr. : 2978517-43-8

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DCLK1-IN-2 Related Antibodies

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Beschreibung

DCLK1-IN-2 (compound I-5) is a potent DCLK1 inhibitor with an IC50 of 171.3  nM. DCLK1-IN-2 shows remarkable antiproliferative effects on SW1990 cell lines (IC50 of 0.6 μM) and in vivo antitumor potency[1].

Cellular Effect
Cell Line Type Value Description References
CAKI-1 IC50
10.1 μM
Compound: I-5
Antiproliferative activity against human CAKI-1 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay
Antiproliferative activity against human CAKI-1 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay
[PMID: 37862816]
HCT-116 IC50
3 μM
Compound: I-5
Antiproliferative activity against human HCT-116 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay
[PMID: 37862816]
SW1990 IC50
0.6 μM
Compound: I-5
Antiproliferative activity against human SW1990 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay
Antiproliferative activity against human SW1990 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay
[PMID: 37862816]
Molekulargewicht

536.65

Formel

C26H32N8O3S
CAS. Nr.
SMILES

CC(C)S(C1=C(NC2=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=NC5=C2N=CN5)C=CC=C1)(=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

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DCLK1-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCLK1-IN-22978517-43-8Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesDCLK1 inhibitorantiproliferative effectsantitumor potencyInhibitorinhibitorinhibit

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