Imipenem monohydrate
Based on 38 publication(s) in Google Scholar
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 74431-23-5
- Formula: C12H19N3O5S
- Molecular Weight:317.36
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Storage:Powder -20°C, 3 years
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Imipenem monohydrate
More- Nat Nanotechnol. 2026 Feb 2. [Abstract]
- Cell Host Microbe. 2024 May 13:S1931-3128(24)00137-9. [Abstract]
- Nat Commun. 2023 Mar 22;14(1):1594. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- J Cachexia Sarcopenia Muscle. 2023 Jun;14(3):1424-1440. [Abstract]
- Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- J Clin Microbiol. 2025 Aug 20:e0084125. [Abstract]
- Commun Biol. 2023 Aug 12;6(1):837. [Abstract]
- Antibiotics (Basel). 2021 Sep 14;10(9):1110. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- Int J Antimicrob Agents. 2025 Jun 4:107550. [Abstract]
- Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106669. [Abstract]
- Sci Rep. 2022 Oct 7;12(1):16814. [Abstract]
- Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
- iScience. 2025 Mar 28;28(5):112311. [Abstract]
- iScience. 2023 Oct 7;26(11):108158. [Abstract]
- Antimicrob Agents Chemother. 2025 May 23:e0024925. [Abstract]
- Antimicrob Agents Chemother. 2024 Oct 29:e0094524. [Abstract]
- Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0133223. [Abstract]
- Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0052823. [Abstract]
- J Antimicrob Chemother. 2026 Feb 2;81(3):dkag034. [Abstract]
- J Antimicrob Chemother. 2025 Nov 5:dkaf408. [Abstract]
- Microbiol Spectr. 2025 May 19:e0307424. [Abstract]
- Microbiol Spectr. 2023 Dec 12;11(6):e0304723. [Abstract]
- J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858. [Abstract]
- Open Forum Infect Dis. 2023 Jan 27;10(2):ofad038. [Abstract]
- J Glob Antimicrob Resist. 2026 Jun 24:S2213-7165(26)00094-9. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- Infect Drug Resist. 2025 Oct 4:18:5239-5247. [Abstract]
- Eur J Clin Microbiol Infect Dis. 2025 Sep 29. [Abstract]
- Anim Dis. 2021;1(1):26. [Abstract]
- Vet Microbiol. 2024 May:292:110046. [Abstract]
- FEBS Open Bio. 2026 Apr 16. [Abstract]
- Future Microbiol. 2025 Oct 13:1-10. [Abstract]
- Authorea. 2025 Sep 17.
- Res Sq. 2024 Nov 26.
Customer Validation & Images
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Biological Activity
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β-lactam |
Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].
| Drug and dose(mg/kg) | Cmax(mg/liter) | Tmax(min) | AUCtot(mg min/liter) | Vz/F(ml/kg) | Vss/F (ml/kg) | CL/F(ml/min/kg) | t1/2(min) | MRT(min) |
| Imipenem | ||||||||
| 8 | 15 (7.1) | 21 (11) | 1,470 (777) | 648 (330) | 721 (343) | 6.7 (3) | 67 (11) | 108 (12) |
| 16 | 34 (6) | 28 (18) | 2,857 (559) | 507 (140) | 543 (121) | 5.8 (1) | 60 (9.1) | 94 (10) |
| 32 | 54 (11) | 18 (6.1) | 4,895 (635) | 516 (75) | 566 (83) | 6.6 (0.8) | 54 (6.5) | 86 (11) |
| 64 | 69 (37) | 15 (9.5) | 6,037 (2,976) | 547 (274) | 617 (308) | 7.4 (3.6) | 43 (22) | 70 (35) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Neutropenic mouse model of biofilm lung infection[3]
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Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
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Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
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Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 74431-23-5
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Appearance Solid
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Molecular Weight 317.36
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Formula C12H19N3O5S
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Color Off-white to yellow
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SMILES
O=C(C(N12)=C(SCCNC=N)C[C@]2([H])[C@@H]([C@H](O)C)C1=O)O.O
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Synonyms
N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate
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Structure Classification
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Initial Source
Streptomyces cattleya
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years * The compound is unstable in solutions, freshly prepared is recommended.
Publications (38)
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Journal Impact Factor
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Most Recent
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Nat Nanotechnol
Ultra-rapid nanoplasmonic colorimetry in microfluidics for antimicrobial susceptibility testing directly from specimens. [Abstract]2026 Feb 2. PMID: 41629481 -
Cell Host Microbe
Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor2α signaling. [Abstract]2024 May 13:S1931-3128(24)00137-9. PMID: 38754418 -
Nat Commun
2023 Mar 22;14(1):1594. PMID: 36949052 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
J Cachexia Sarcopenia Muscle
2023 Jun;14(3):1424-1440. PMID: 36883680 -
Free Radic Biol Med
Atorvastatin combined with imipenem alleviates lung injury in sepsis by inhibiting neutrophil extracellular trap formation via the ERK/NOX2 signaling pathway. [Abstract]2024 Aug 1:220:179-191. PMID: 38704053
Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. The protein levels of Cit-H3 in the lungs were detected by western blot and analyzed by grayscale.
Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. Co-localization of Cit-H3, MPO and DAPI was observed by fluorescence microscopy and the level of NETs formation was analyzed (n = 4).
Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. HE staining and scoring of lung tissue, scale bar = 100 μm.
Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. Co-localization of Cit-H3, MPO and DAPI in NET was observed using fluorescence microscopy
Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Imipenem monohydrate (1, 5, 10 μM) was pre-treated with neutrophils for 2 h, followed by stimulation with LPS (5 μg/mL) for 4 h. Cit-H3 was detected by western blot.
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Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
J Clin Microbiol
Luciferase reporter mycobacteriophage (TM4:: GeNL) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complex. [Abstract]2025 Aug 20:e0084125. PMID: 40833127 -
Commun Biol
Bacteria exposed to antiviral drugs develop antibiotic cross-resistance and unique resistance profiles. [Abstract]2023 Aug 12;6(1):837. PMID: 37573457 -
Antibiotics (Basel)
Rapid Detection of Multiple Classes of β-Lactam Antibiotics in Blood Using an NDM-1 Biosensing Assay. [Abstract]2021 Sep 14;10(9):1110. PMID: 34572692 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Int J Antimicrob Agents
In vitro activity of cefepime-zidebactam, ceftolozane-tazobactam, ceftazidime-avibactam, imipenem-relebactam, and other comparators against imipenem-non-susceptible Pseudomonas aeruginosa in Taiwan, 2022. [Abstract]2025 Jun 4:107550. PMID: 40480535 -
Int J Antimicrob Agents
In vitro effects of diazabicyclooctane β-lactamase inhibitors relebactam and nacubactam against three subspecies of Mycobacterium abscessus complex. [Abstract]2022 Nov-Dec;60(5-6):106669. PMID: 36064079 -
Sci Rep
Activity of newest generation β-lactam/β-lactamase inhibitor combination therapies against multidrug resistant Pseudomonas aeruginosa. [Abstract]2022 Oct 7;12(1):16814. PMID: 36207358 -
Microorganisms
Antimicrobial Resistance and Genomic Characteristics of Escherichia coli Strains Isolated from the Poultry Industry in Henan Province, China. [Abstract]2024 Mar 13;12(3):575. PMID: 38543626
Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.
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iScience
The oxacillinase variant, OXA-1152, in Pandoraea sputorum contributes to discrepancies in carbapenem resistance. [Abstract]2025 Mar 28;28(5):112311. PMID: 40454099 -
iScience
Analysis of microbiota reveals the underlying mechanism of PHF11 in the development of Enterococcus-regulated endometriotic cysts. [Abstract]2023 Oct 7;26(11):108158. PMID: 37915596 -
Antimicrob Agents Chemother
An enoyl-ACP reductase inhibitor, NITD-916, expresses anti- Mycobacterium abscessus activity. [Abstract]2025 May 23:e0024925. PMID: 40407337
Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2025 May 23:e0024925. [Abstract]
Numbers of organisms treated with 16× MIC NITD-916, 8 mg/L RFB or 16 mg/L IPM at 24 and 48 hours were significantly less than the drug-free control.
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Antimicrob Agents Chemother
2024 Oct 29:e0094524. PMID: 39470202 -
Antimicrob Agents Chemother
2024 Feb 7;68(2):e0133223. PMID: 38174924 -
Antimicrob Agents Chemother
The in vitro effect of new combinations of carbapenem-β-lactamase inhibitors for Mycobacterium abscessus. [Abstract]2023 Oct 18;67(10):e0052823. PMID: 37671880 -
J Antimicrob Chemother
Comparative activity of established versus new-generation β-lactams against AmpC-hyperproducing clinical isolates of Enterobacter cloacae complex and Klebsiella aerogenes: a multicentre study. [Abstract]2026 Feb 2;81(3):dkag034. PMID: 41648989 -
J Antimicrob Chemother
Unravelling the triad of penicillin-binding proteins, β-lactamase activity, and mRNA dynamics in Pseudomonas aeruginosa AmpC induction. [Abstract]2025 Nov 5:dkaf408. PMID: 41206063 -
Microbiol Spectr
Antimicrobial resistance of rapidly growing mycobacteria isolated from companion animals in Taiwan. [Abstract]2025 May 19:e0307424. PMID: 40387379 -
Microbiol Spectr
In vitro activity of cefiderocol against Pseudomonas aeruginosa isolated from cystic fibrosis patients. [Abstract]2023 Dec 12;11(6):e0304723. PMID: 37982634 -
J Antimicrob Chemother
In vitro activity of the novel β-lactamase inhibitor taniborbactam (VNRX-5133), in combination with cefepime or meropenem, against MDR Gram-negative bacterial isolates from China. [Abstract]2020 Jul 1;75(7):1850-1858. PMID: 32154866 -
Open Forum Infect Dis
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type. [Abstract]2023 Jan 27;10(2):ofad038. PMID: 36776778 -
J Glob Antimicrob Resist
In vitro activity of cefiderocol against clinically relevant Gram-negative bacilli collected in China in 2023. [Abstract]2026 Jun 24:S2213-7165(26)00094-9. PMID: 42342122 -
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Infect Drug Resist
In vitro Activity of the Novel Tetracyclines Derivative, Zifanocycline Against Mycobacterium abscessus. [Abstract]2025 Oct 4:18:5239-5247. PMID: 41069760 -
Eur J Clin Microbiol Infect Dis
Evaluation of EUCAST rapid antimicrobial susceptibility testing (RAST) for carbapenemase-producing Klebsiella pneumoniae with focus on KPC variants. [Abstract]2025 Sep 29. PMID: 41023358 -
Anim Dis
Pasteurella multocida capsular: lipopolysaccharide types D:L6 and A:L3 remain to be the main epidemic genotypes of pigs in China. [Abstract]2021;1(1):26. PMID: 34778886 -
Vet Microbiol
Discovery of the tigecycline resistance gene cluster tmexCD3-toprJ1 in Pasteurella multocida strains isolated from pigs in China. [Abstract]2024 May:292:110046. PMID: 38471428 -
FEBS Open Bio
Long-term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis. [Abstract]2026 Apr 16. PMID: 41992425 -
Future Microbiol
2025 Oct 13:1-10. PMID: 41082411 -
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Solvent & Solubility
H2O : 6.25 mg/mL (19.69 mM; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (31.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808. [Content Brief]
[2]. Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90 [Content Brief]
[3]. F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 3.1510 mL | 15.7550 mL | 31.5100 mL | 78.7749 mL |
| 5 mM | 0.6302 mL | 3.1510 mL | 6.3020 mL | 15.7550 mL | |
| 10 mM | 0.3151 mL | 1.5755 mL | 3.1510 mL | 7.8775 mL | |
| 15 mM | 0.2101 mL | 1.0503 mL | 2.1007 mL | 5.2517 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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