N4BP3 - NEDD4 binding protein 3 Gene

Also Known as LZTS4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23138

About N4BP3

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:178,113,532-178,127,034 (from NCBI)

This gene has 1 transcript (splice variant) and 197 orthologues. Broad expression in placenta (RPKM 5.5), esophagus (RPKM 3.2) and 20 other tissues.

Summary

Predicted to be involved in nervous system development. Predicted to be located in axon and dendrite. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

N4BP3 Products (1)

mRNA Protein Name
NM_015111.2 NP_055926.1 NEDD4-binding protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IDA
IDA: Inferred from direct assay
34880843 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26496610 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of positive effect innate immune response IDA
IDA: Inferred from direct assay
23951545 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

N4BP3 Protein Structure

Fez1

Fez1: Fez1 (366 - 428)

Fez1

Fez1: Fez1 (441 - 526)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 544 a.a.
Protein Preferred Names Protein Names

NEDD4-binding protein 3

N4BP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
N4BP3 O15049 CNKSR3 Homo sapiens Q6P9H4
Validated Y2H
32296183
Intra
N4BP3 O15049 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra
N4BP3 O15049 PRR35 Homo sapiens P0CG20
Validated Y2H
32296183
Intra
N4BP3 O15049 CCDC17 Homo sapiens Q96LX7-5
Validated Y2H
32296183
Intra
N4BP3 O15049 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra
N4BP3 O15049 LMO4 Homo sapiens P61968
Validated Y2H
32296183
Intra
N4BP3 O15049 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra
N4BP3 O15049 RFC5 Homo sapiens P40937
Validated Y2H
32296183
Intra
N4BP3 O15049 UBASH3A Homo sapiens P57075-2
Validated Y2H
32296183
Intra
N4BP3 O15049 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
N4BP3 O15049 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
N4BP3 O15049 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 5

  • Epileptic Encephalopathy, Early Infantile, 5

  • DEE5

  • Eiee5

  • Developmental And Epileptic Encephalopathy, 5

  • Early Infantile Epileptic Encephalopathy 5

  • Encephalopathy, Epileptic, Early Infantile, Type 5
Developmental And Epileptic Encephalopathy 4

  • DEE4

  • Epileptic Encephalopathy, Early Infantile, 4

  • Eiee4

  • Early Infantile Epileptic Encephalopathy 4

  • Stxbp1-Related Early-Onset Encephalopathy

  • Early Myoclonic Encephalopathy

  • Developmental And Epileptic Encephalopathy, 4

  • Stxbp1 Disorders

  • Stxbp1 Encephalopathy

  • Developmental And Epileptic Encephalopathy, Type 4

  • Early-Infantile Epileptic Encephalopathy 4

  • Stxbp1 Encephalopathy With Epilepsy

  • Stxbp1 Epileptic Encephalopathy

  • Stxbp1-Related Developmental And Epileptic Encephalopathy

  • Stxbp1-Related Epileptic Encephalopathy

  • Eme

  • Neonatal Epilepsy With Suppression-Burst Pattern

  • Encephalopathy, Epileptic, Early Infantile, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08983 N4BP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus N4BP3 RGD RGD:1308356
Macaca mulatta N4BP3 VGNC VGNC:75053
Bos taurus N4BP3 VGNC VGNC:31853
Canis familiaris N4BP3 VGNC VGNC:43598
Felis catus N4BP3 VGNC VGNC:102262
Mus musculus N4BP3 MGD MGI:2442218
Others N4BP3 NCBI