ARL6IP1 - ADP ribosylation factor like GTPase 6 interacting protein 1 Gene

Also Known as AIP1; ARMER; SPG61; ARL6IP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23204

About ARL6IP1

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:18,791,667-18,801,549 (from NCBI)

This gene has 8 transcripts (splice variants), 219 orthologues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 151.5), adrenal (RPKM 96.4) and 25 other tissues.

Summary

This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

ARL6IP1 Products (2)

mRNA Protein Name
NM_001313858.1 NP_001300787.1 ADP-ribosylation factor-like protein 6-interacting protein 1 isoform 2
NM_015161.3 NP_055976.1 ADP-ribosylation factor-like protein 6-interacting protein 1 isoform 1
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12754298 GOA
is active in endoplasmic reticulum tubular network IDA
IDA: Inferred from direct assay
35346366 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL6IP1 Protein Structure

Reticulon

Reticulon: Reticulon (34 - 193)

  • 0
  • 100
  • 203 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 6-interacting protein 1

  • ADP-ribosylation factor GTPase 6 interacting protein 1

ARL6IP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARL6IP1 Q15041 SUCLA2 Homo sapiens E5KS60 25416956
Intra
ARL6IP1 Q15041 UBE2I Homo sapiens Q7KZS0 32296183
Intra
ARL6IP1 Q15041 UBE2I Homo sapiens Q7KZS0 32296183
Intra
ARL6IP1 Q15041 UBE2I Homo sapiens Q7KZS0 32296183
Intra
ARL6IP1 Q15041 RETREG3 Homo sapiens Q86VR2 32296183
Intra
ARL6IP1 Q15041 RETREG3 Homo sapiens Q86VR2 25416956
Intra
ARL6IP1 Q15041 RETREG3 Homo sapiens Q86VR2 29892012
Intra
ARL6IP1 Q15041 RETREG3 Homo sapiens Q86VR2 32296183
Intra
ARL6IP1 Q15041 RETREG3 Homo sapiens Q86VR2 32296183
Intra
ARL6IP1 Q15041 PBX3 Homo sapiens Q5JS98 25416956
Intra
ARL6IP1 Q15041 SNX10 Homo sapiens Q8N5Z3 25416956
Intra
ARL6IP1 Q15041 SNX10 Homo sapiens Q8N5Z3 25416956
Intra
ARL6IP1 Q15041 TMEM248 Homo sapiens Q9NWD8 32296183
Intra
ARL6IP1 Q15041 TMEM248 Homo sapiens Q9NWD8 32296183
Intra
ARL6IP1 Q15041 TMEM248 Homo sapiens Q9NWD8 32296183
Intra
ARL6IP1 Q15041 NDRG4 Homo sapiens Q9ULP0 25416956
Intra
ARL6IP1 Q15041 SNX11 Homo sapiens Q9Y5W9 25416956
Intra
ARL6IP1 Q15041 SNX11 Homo sapiens Q9Y5W9 32296183
Intra
ARL6IP1 Q15041 SNX11 Homo sapiens Q9Y5W9 25416956
Intra
ARL6IP1 Q15041 SNX10 Homo sapiens Q9Y5X0 32296183
Intra
ARL6IP1 Q15041 SNX10 Homo sapiens Q9Y5X0 25416956
Intra
ARL6IP1 Q15041 SNX10 Homo sapiens Q9Y5X0 25416956
Intra
ARL6IP1 Q15041 TARS2 Homo sapiens Q9BW92 32296183
Intra
ARL6IP1 Q15041 TFAM Homo sapiens Q00059 25416956
Intra
ARL6IP1 Q15041 TFAM Homo sapiens Q00059 25416956
Intra
ARL6IP1 Q15041 VMA21 Homo sapiens Q3ZAQ7 32296183
Intra
ARL6IP1 Q15041 VMA21 Homo sapiens Q3ZAQ7 32296183
Intra
ARL6IP1 Q15041 VMA21 Homo sapiens Q3ZAQ7 32296183
Intra
ARL6IP1 Q15041 CERT1 Homo sapiens Q9Y5P4-2 32296183
Intra
ARL6IP1 Q15041 TMED8 Homo sapiens Q6PL24 32296183
Intra
ARL6IP1 Q15041 GPR151 Homo sapiens Q8TDV0 32296183
Intra
ARL6IP1 Q15041 GPR151 Homo sapiens Q8TDV0 32296183
Intra
ARL6IP1 Q15041 GPR151 Homo sapiens Q8TDV0 32296183
Intra
ARL6IP1 Q15041 NDRG4 Homo sapiens Q9ULP0-2 32296183
Intra
ARL6IP1 Q15041 MIEF2 Homo sapiens Q96C03-3 32296183
Intra
ARL6IP1 Q15041 TMEM258 Homo sapiens P61165 32296183
Intra
ARL6IP1 Q15041 TMEM258 Homo sapiens P61165 32296183
Intra
ARL6IP1 Q15041 AQP6 Homo sapiens Q13520 32296183
Intra
ARL6IP1 Q15041 AQP6 Homo sapiens Q13520 32296183
Intra
ARL6IP1 Q15041 GPR152 Homo sapiens Q8TDT2 32296183
Intra
ARL6IP1 Q15041 GPR152 Homo sapiens Q8TDT2 32296183
Intra
ARL6IP1 Q15041 GPR152 Homo sapiens Q8TDT2 32296183
Intra
ARL6IP1 Q15041 SHISA5 Homo sapiens Q8N114-3 32296183
Intra
ARL6IP1 Q15041 SHISA5 Homo sapiens Q8N114-3 32296183
Intra
ARL6IP1 Q15041 SHISA5 Homo sapiens Q8N114-3 32296183
Intra
ARL6IP1 Q15041 REEP6 Homo sapiens Q96HR9-2 32296183
Intra
ARL6IP1 Q15041 REEP6 Homo sapiens Q96HR9-2 32296183
Intra
ARL6IP1 Q15041 REEP6 Homo sapiens Q96HR9-2 32296183
Intra
ARL6IP1 Q15041 STARD4 Homo sapiens Q96DR4 32296183
Intra
ARL6IP1 Q15041 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
Intra
ARL6IP1 Q15041 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
Intra
ARL6IP1 Q15041 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
Intra
ARL6IP1 Q15041 SNX8 Homo sapiens Q9Y5X2 32296183
Intra
ARL6IP1 Q15041 SNX12 Homo sapiens Q9UMY4 25416956
Intra
ARL6IP1 Q15041 SNX12 Homo sapiens Q9UMY4 25416956
Intra
ARL6IP1 Q15041 HSD17B13 Homo sapiens Q7Z5P4 32296183
Intra
ARL6IP1 Q15041 HSD17B13 Homo sapiens Q7Z5P4 32296183
Intra
ARL6IP1 Q15041 HSD17B13 Homo sapiens Q7Z5P4 32296183
Intra
ARL6IP1 Q15041 SLC10A6 Homo sapiens Q3KNW5 32296183
Intra
ARL6IP1 Q15041 SLC10A6 Homo sapiens Q3KNW5 32296183
Intra
ARL6IP1 Q15041 SLC10A6 Homo sapiens Q3KNW5 32296183
Intra
ARL6IP1 Q15041 C19orf18 Homo sapiens Q8NEA5 32296183
Intra
ARL6IP1 Q15041 C19orf18 Homo sapiens Q8NEA5 32296183
Intra
ARL6IP1 Q15041 C19orf18 Homo sapiens Q8NEA5 32296183
Intra
ARL6IP1 Q15041 SNX12 Homo sapiens Q9UMY4-1 32296183
Intra
ARL6IP1 Q15041 SUCLA2 Homo sapiens Q9P2R7 32296183
Intra
ARL6IP1 Q15041 GOLPH3 Homo sapiens Q9H4A6 25416956
Intra
ARL6IP1 Q15041 MCEMP1 Homo sapiens Q8IX19 32296183
Intra
ARL6IP1 Q15041 MCEMP1 Homo sapiens Q8IX19 32296183
Intra
ARL6IP1 Q15041 MCEMP1 Homo sapiens Q8IX19 32296183
Intra
ARL6IP1 Q15041 SNX1 Homo sapiens Q13596 25416956
Intra
ARL6IP1 Q15041 SNX1 Homo sapiens Q13596
Y2H
21516116
Intra
ARL6IP1 Q15041 ZFYVE21 Homo sapiens Q9BQ24 32296183
Intra
ARL6IP1 Q15041 EHD3 Homo sapiens Q9NZN3 32296183
Intra
ARL6IP1 Q15041 EHD3 Homo sapiens Q9NZN3 32296183
Intra
ARL6IP1 Q15041 EHD3 Homo sapiens Q9NZN3 32296183
Intra
ARL6IP1 Q15041 ACSF2 Homo sapiens Q96CM8 25416956
Intra
ARL6IP1 Q15041 ACSF2 Homo sapiens Q96CM8
Y2H
21516116
Intra
ARL6IP1 Q15041 ACSF2 Homo sapiens Q96CM8 25416956
Intra
ARL6IP1 Q15041 ACSF2 Homo sapiens Q96CM8 25416956
Intra
ARL6IP1 Q15041 ACSF2 Homo sapiens Q96CM8 31515488
Intra
ARL6IP1 Q15041 ACSF2 Homo sapiens Q96CM8 32296183
Intra
ARL6IP1 Q15041 RNF5 Homo sapiens Q99942 32296183
Intra
ARL6IP1 Q15041 RNF5 Homo sapiens Q99942 32296183
Intra
ARL6IP1 Q15041 RNF5 Homo sapiens Q99942 32296183
Intra
ARL6IP1 Q15041 SHMT2 Homo sapiens P34897 25416956
Intra
ARL6IP1 Q15041 MFSD14B Homo sapiens Q5SR56 32296183
Intra
ARL6IP1 Q15041 MFSD14B Homo sapiens Q5SR56 32296183
Intra
ARL6IP1 Q15041 MFSD14B Homo sapiens Q5SR56 32296183
Intra
ARL6IP1 Q15041 MFSD5 Homo sapiens Q6N075 32296183
Intra
ARL6IP1 Q15041 MFSD5 Homo sapiens Q6N075 32296183
Intra
ARL6IP1 Q15041 MFSD5 Homo sapiens Q6N075 32296183
Intra
ARL6IP1 Q15041 NAPB Homo sapiens Q9H115 25416956
Intra
ARL6IP1 Q15041 NAPB Homo sapiens Q9H115 25416956
Intra
ARL6IP1 Q15041 EMP1 Homo sapiens P54849 32296183
Intra
ARL6IP1 Q15041 EMP1 Homo sapiens P54849 32296183
Intra
ARL6IP1 Q15041 DIABLO Homo sapiens Q9NR28 25416956
Intra
ARL6IP1 Q15041 DIABLO Homo sapiens Q9NR28 25416956
Intra
ARL6IP1 Q15041 DIABLO Homo sapiens Q9NR28 32296183
Intra
ARL6IP1 Q15041 DIABLO Homo sapiens Q9NR28 25416956
Intra
ARL6IP1 Q15041 MYG1 Homo sapiens Q9HB07 25416956
Intra
ARL6IP1 Q15041 MYG1 Homo sapiens Q9HB07 32296183
Intra
ARL6IP1 Q15041 MYG1 Homo sapiens Q9HB07 25416956
Intra
ARL6IP1 Q15041 CERT1 Homo sapiens Q9Y5P4 25416956
Intra
ARL6IP1 Q15041 SENP2 Homo sapiens Q9HC62 25416956
Intra
ARL6IP1 Q15041 SENP2 Homo sapiens Q9HC62 25416956
Intra
ARL6IP1 Q15041 RTN4 Homo sapiens Q9NQC3 25416956
Intra
ARL6IP1 Q15041 RTN4 Homo sapiens Q9NQC3 25416956
Intra
ARL6IP1 Q15041 PAM16 Homo sapiens Q9Y3D7 25416956
Intra
ARL6IP1 Q15041 MGST3 Homo sapiens O14880 32296183
Intra
ARL6IP1 Q15041 MGST3 Homo sapiens O14880 32296183
Intra
ARL6IP1 Q15041 SNX4 Homo sapiens O95219 25416956
Intra
ARL6IP1 Q15041 SNX4 Homo sapiens O95219 25416956
Intra
ARL6IP1 Q15041 SNX4 Homo sapiens O95219 25416956
Intra
ARL6IP1 Q15041 SNX15 Homo sapiens Q9NRS6 31515488
Intra
ARL6IP1 Q15041 SNX15 Homo sapiens Q9NRS6 25416956
Intra
ARL6IP1 Q15041 SNX3 Homo sapiens O60493 25416956
Intra
ARL6IP1 Q15041 GORASP2 Homo sapiens Q9H8Y8 25416956
Intra
ARL6IP1 Q15041 GORASP2 Homo sapiens Q9H8Y8 25416956
Intra
ARL6IP1 Q15041 GORASP2 Homo sapiens Q9H8Y8 25416956
Intra
ARL6IP1 Q15041 GORASP2 Homo sapiens Q9H8Y8 29892012
Intra
ARL6IP1 Q15041 CERT1 Homo sapiens Q9Y5P4 29892012
Intra
ARL6IP1 Q15041 CERT1 Homo sapiens Q9Y5P4 31515488
Intra
ARL6IP1 Q15041 NTAQ1 Homo sapiens Q96HA8 32296183
Intra
ARL6IP1 Q15041 SPG21 Homo sapiens Q9NZD8 25416956
Intra
ARL6IP1 Q15041 SPG21 Homo sapiens Q9NZD8 32296183
Intra
ARL6IP1 Q15041 SPG21 Homo sapiens Q9NZD8 25416956
Intra
ARL6IP1 Q15041 RAB33A Homo sapiens Q14088 25416956
Intra
ARL6IP1 Q15041 RAB33A Homo sapiens Q14088 25416956
Intra
ARL6IP1 Q15041 INPP5K Homo sapiens Q9BT40 29892012
Intra
ARL6IP1 Q15041 INPP5K Homo sapiens Q9BT40 16189514
Intra
ARL6IP1 Q15041 INPP5K Homo sapiens Q9BT40 32296183
Intra
ARL6IP1 Q15041 YIPF4 Homo sapiens Q9BSR8 32296183
Intra
ARL6IP1 Q15041 YIPF4 Homo sapiens Q9BSR8 32296183
Intra
ARL6IP1 Q15041 YIPF4 Homo sapiens Q9BSR8 32296183
Intra
ARL6IP1 Q15041 MTERF3 Homo sapiens Q96E29 25416956
Intra
ARL6IP1 Q15041 PICK1 Homo sapiens Q9NRD5 32296183
Intra
ARL6IP1 Q15041 TMEM14B Homo sapiens Q9NUH8 32296183
Intra
ARL6IP1 Q15041 TMEM14B Homo sapiens Q9NUH8 32296183
Intra
ARL6IP1 Q15041 TMEM14B Homo sapiens Q9NUH8 32296183
Intra
ARL6IP1 Q15041 GAD2 Homo sapiens Q05329 25416956
Intra
ARL6IP1 Q15041 WDFY2 Homo sapiens Q96P53 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spastic Paraplegia 61, Autosomal Recessive
  • SPG61

  • Hereditary Spastic Paraplegia 61

  • Autosomal Recessive Spastic Paraplegia Type 61

  • Autosomal Recessive Spastic Paraplegia 61

  • Paraplegia, Spastic, Type 61, Autosomal Recessive

Paraplegia
  • Paraplegia, Lower

  • Severe Or Complete Loss Of Motor Function In The Lower Extremities And Lower Portions Of The Trunk

Spastic Paraplegia 57, Autosomal Recessive
  • SPG57

  • Hereditary Spastic Paraplegia 57

  • Autosomal Recessive Spastic Paraplegia Type 57

  • Autosomal Recessive Spastic Paraplegia 57

  • Spastic Paraplegia Due To Partial Tfg Deficiency

  • Paraplegia, Spastic, Type 57, Autosomal Recessive

Microcephaly, Seizures, And Developmental Delay
  • MCSZ

  • Developmental And Epileptic Encephalopathy 10

  • Epileptic Encephalopathy, Early Infantile, 10

  • Eiee10

  • Dee10

  • Early Infantile Epileptic Encephalopathy 10

Spastic Paraplegia 73, Autosomal Dominant
  • SPG73

  • Hereditary Spastic Paraplegia 73

  • Autosomal Dominant Spastic Paraplegia Type 73

  • Autosomal Dominant Spastic Paraplegia 73

  • Paraplegia, Spastic, Autosomal Dominant, Type 73

Ayme-Gripp Syndrome
  • AYGRP

  • Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation

  • Aymé-Gripp Syndrome

  • Fine-Lubinsky Syndrome

  • Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome

  • Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome

Spastic Paraplegia 43, Autosomal Recessive
  • SPG43

  • Hereditary Spastic Paraplegia 43

  • Autosomal Recessive Spastic Paraplegia Type 43

  • Autosomal Recessive Spastic Paraplegia 43

  • Paraplegia, Spastic, Type 43, Autosomal Recessive

Pettigrew Syndrome
  • PGS

  • Mrxs5

  • Mrx59

  • Mrxs21

  • X-Linked Intellectual Disability-Dandy-Walker Malformation-Basal Ganglia Disease-Seizures Syndrome

  • Mental Retardation, X-Linked, Syndromic 5

  • Mrxsf

  • Syndromic X-Linked Intellectual Disability 5

  • Fried Syndrome

  • Mental Retardation, X-Linked Syndromic 5

  • Mental Retardation, X-Linked, With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures

  • Mental Retardation, X-Linked, Syndromic, Fried Type

  • Mental Retardation, X-Linked, Syndromic 21

  • Syndromic X-Linked Mental Retardation 21

  • Syndromic X-Linked Mental Retardation Fried Type

  • X-Linked Metal Retardation With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures

  • Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease An

  • Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease And Seizures

  • X-Linked Syndromic Intellectual Disability 5

  • X-Linked Intellectual Disability With Dandy-Walker Malformation Basal Ganglia Disease And Seizures

  • X-Linked Intellectual Disability - Dandy-Walker Malformation - Basal Ganglia Disease - Seizures

  • X-Linked Intellectual Disability-Hypotonia-Facial Dysmorphism-Aggressive Behavior Syndrome

  • Mental Retardation, X-Linked Syndromic, Fried Type

  • Dandy-Walker Malformation With Mental Retardation, Basal Ganglia Disease, And Seizures

  • Mental Retardation, X-Linked 59

Motor Neuron Disease
  • Anterior Horn Cell Disease

  • Motor Neuron Diseases

  • Mnd - [Motor Neurone Disease]

  • Lou Gehrig Disease

  • Creeping Palsy

  • Creeping Paralysis

  • Bulbar Motor Neuron Disease

  • Bulbar Syndrome

  • Anterior Horn Cell Disorder

  • Hereditary Motor Neuron Disease

Hereditary Spastic Paraplegia
  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia

Spastic Ataxia
  • Spax

  • Ataxia, Spastic

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARL6IP1 RGD RGD:735205
Mus musculus ARL6IP1 MGD MGI:1858943
Bos taurus ARL6IP1 VGNC VGNC:26150
Others ARL6IP1 NCBI