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RAB33A - RAB33A, member RAS oncogene family Gene

Also Known as RabS10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9363

About RAB33A

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:130,110,623-130,184,870 (from NCBI)

This gene has 1 transcript (splice variant), 183 orthologues and 68 paralogues. Biased expression in brain (RPKM 10.9), lymph node (RPKM 3.6) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may be involved in vesicle transport. [provided by RefSeq, Jul 2008]

RAB33A Products (1)

mRNA	Protein	Name
NM_004794.3	NP_004785.1	ras-related protein Rab-33A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	19717423	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB33A Protein Structure

Ras

0
100
200
237 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-33A	Small GTP-binding protein S10

RAB33A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	RAB33A	Q14088	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	RAB33A	Q14088	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	RAB33A	Q14088	LRP2BP	Homo sapiens	Q9P2M1	Y2H Array	32296183
Intra	RAB33A	Q14088	LRP2BP	Homo sapiens	Q9P2M1	Y2H Prey Pooling	32296183
Intra	RAB33A	Q14088	LRP2BP	Homo sapiens	Q9P2M1	Validated Y2H	32296183
Intra	RAB33A	Q14088	RUFY2	Homo sapiens	Q8WXA3-4	Validated Y2H	32296183
Intra	RAB33A	Q14088	RUFY2	Homo sapiens	Q8WXA3-4	Y2H Prey Pooling	32296183
Intra	RAB33A	Q14088	RUFY2	Homo sapiens	Q8WXA3-4	Y2H Array	32296183
Intra	RAB33A	Q14088	ATG16L1	Homo sapiens	Q676U5	Anti Tag CoIP	33961781
Intra	RAB33A	Q14088	ATG16L1	Homo sapiens	Q676U5	Y2H Prey Pooling	32296183
Intra	RAB33A	Q14088	ATG16L1	Homo sapiens	Q676U5	Validated Y2H	32296183
Intra	RAB33A	Q14088	ATG16L1	Homo sapiens	Q676U5	Y2H Array	32296183
Intra	RAB33A	Q14088	RABAC1	Homo sapiens	Q9UI14	Y2H Array	19060904
Intra	RAB33A	Q14088	RABAC1	Homo sapiens	Q9UI14	Y2H Pooling	19060904
Intra	RAB33A	Q14088	RABAC1	Homo sapiens	Q9UI14	Y2H Pooling	16189514
Intra	RAB33A	Q14088	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
Intra	RAB33A	Q14088	RUFY3	Homo sapiens	Q7L099	Y2H Array	32296183
Intra	RAB33A	Q14088	RUFY3	Homo sapiens	Q7L099	Y2H Prey Pooling	32296183
Intra	RAB33A	Q14088	RUFY3	Homo sapiens	Q7L099	Validated Y2H	32296183
Intra	RAB33A	Q14088	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	RAB33A	Q14088	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	RAB33A	Q14088	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	RAB33A	Q14088	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956
Intra	RAB33A	Q14088	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	RAB33A	Q14088	PSMF1	Homo sapiens	Q92530	Y2H Prey Pooling	32296183
Intra	RAB33A	Q14088	PSMF1	Homo sapiens	Q92530	Validated Y2H	32296183
Intra	RAB33A	Q14088	PSMF1	Homo sapiens	Q92530	Y2H Array	32296183
Intra	RAB33A	Q14088	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	RAB33A	Q14088	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	RAB33A	Q14088	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency
Spondyloepimetaphyseal Dysplasia, X-Linked, With Hypomyelinating Leukodystrophy	SEMDHL Leukoencephalopathy With Metaphyseal Chondrodysplasia H-Smd Leukoencephalopathy-Metaphyseal Chondrodysplasia Syndrome Lkmcd Semd, X-Linked, With Mental Deterioration Leukoencephalopathy-Spondylometaphyseal Dysplasia Syndrome Hypomyelination-Spondylometaphyseal Dysplasia Syndrome X-Linked Spondyloepimetaphyseal Dysplasia With Hypomyelinating Leukodystrophy Leukoencephalopathy-Spondyloepimetaphyseal Dysplasia Syndrome Hypomyelination-Spondyloepimetaphyseal Dysplasia Syndrome Leukoencephalopathy-Semd Syndrome Semd X-Linked With Mental Deterioration
Deafness, X-Linked 5, With Peripheral Neuropathy	Deafness, X-Linked 5 DFNX5 Aunx1 Auditory Neuropathy, X-Linked, 1, With Peripheral Sensory Neuropathy X-Linked Deafness 5 X-Linked Auditory Neuropathy With Peripheral Sensory Neuropathy Type 1 X-Linked Hsan With Deafness X-Linked Auditory Neuropathy 1 With Peripheral Sensory Neuropathy X-Linked Hereditary Sensory And Autonomic Neuropathy With Deafness X-Linked Hsan With Hearing Loss X-Linked Hereditary Sensory And Autonomic Neuropathy With Hearing Loss Deafness, X-Linked, 5, With Peripheral Neuropathy Deafness, X-Linked, Type 5
Combined Oxidative Phosphorylation Deficiency 6	Severe X-Linked Mitochondrial Encephalomyopathy COXPD6 Mitochondrial Encephalomyopathy Due To Combined Oxidative Phosphorylation Defect 6 Mitochondrial Encephalomyopathy Due To Coxpd6 Encephalomyopathy, Mitochondrial, X-Linked Encephalomyopathy Mitochondrial X-Linked Oxidative Phosphorylation Deficiency, Combined, Type 6
Charcot-Marie-Tooth Disease X-Linked Recessive 4	Cmt4x Cmtx4 Cowchock Syndrome X-Linked Charcot-Marie-Tooth Disease Type 4 Axonal Motor Sensory Neuropathy With Deafness And Mental Retardation Charcot-Marie-Tooth Disease With Deafness And Mental Retardation Nadmr Namsd
Charcot-Marie-Tooth Disease, X-Linked Recessive, 4, With Or Without Cerebellar Ataxia	Cowchock Syndrome CMTX4 Cowck Neuropathy, Axonal Motor-Sensory, With Deafness And Mental Retardation Namsd Nadmr Charcot-Marie-Tooth Disease With Deafness And Mental Retardation Charcot-Marie-Tooth Disease Deafness Mental Retardation Charcot-Marie-Tooth Disease X-Linked Recessive 4
Hypomyelinating Leukodystrophy	Hld Leukodystrophy, Hypomyelinating
Leukodystrophy	Leukodystrophies
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Developmental And Epileptic Encephalopathy 33	DEE33 Epileptic Encephalopathy, Early Infantile, 33 Eiee33 Developmental And Epileptic Encephalopathy, 33 Early Infantile Epileptic Encephalopathy 33 Encephalopathy, Epileptic, Early Infantile, Type 33
Prostate Transitional Cell Carcinoma	Transitional Cell Carcinoma Of Prostate Primary Prostate Urothelial Carcinoma
Dyggve-Melchior-Clausen Disease	Dyggve-Melchior-Clausen Syndrome DMC Dmc Disease Pseudo-Morquio Disease Type I Dmc Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS11546	RAB33A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RAB33A	VGNC	VGNC:45275
Rattus norvegicus	RAB33A	RGD	RGD:1563280
Bos taurus	RAB33A	VGNC	VGNC:33642
Mus musculus	RAB33A	MGD	MGI:109493
Others	RAB33A	NCBI