SNX8 - sorting nexin 8 Gene

Also Known as Mvp1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29886

About SNX8

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:2,251,770-2,354,497 (from NCBI)

This gene has 9 transcripts (splice variants), 220 orthologues and 15 paralogues. Broad expression in spleen (RPKM 12.6), testis (RPKM 7.0) and 24 other tissues.

Summary

Enables identical protein binding activity and phosphatidylinositol binding activity. Involved in early endosome to Golgi transport and intracellular protein transport. Located in early endosome membrane. Colocalizes with retromer complex. [provided by Alliance of Genome Resources, Apr 2022]

SNX8 Products (1)

mRNA	Protein	Name
NM_013321.4	NP_037453.1	sorting nexin-8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23085988	GOA
enables phosphatidylinositol binding	IMP IMP: Inferred from mutant phenotype	19782049	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in early endosome to Golgi transport	IMP IMP: Inferred from mutant phenotype	19782049	GOA
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	19782049	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	19782049	GOA
part of retromer complex	IDA IDA: Inferred from direct assay	19782049	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX8 Protein Structure

PX

0
100
200
300
400
465 a.a.

Protein Preferred Names	Protein Names
sorting nexin-8

SNX8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNX8	Q9Y5X2	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	SNX8	Q9Y5X2	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	SNX8	Q9Y5X2	POR	Homo sapiens	P16435	Anti Tag CoIP	28514442
Intra	SNX8	Q9Y5X2	RABAC1	Homo sapiens	Q9UI14	Y2H Prey Pooling	32296183
Intra	SNX8	Q9Y5X2	FBXW7	Homo sapiens	Q969H0	Anti Tag CoIP	33961781
Intra	SNX8	Q9Y5X2	FBXW7	Homo sapiens	Q969H0	Anti Tag CoIP	28514442
Intra	SNX8	Q9Y5X2	RABAC1	Homo sapiens	Q9UI14	Y2H Array	32296183
Intra	SNX8	Q9Y5X2	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	SNX8	Q9Y5X2	LACC1	Homo sapiens	Q8IV20	Anti Tag CoIP	33961781
Intra	SNX8	Q9Y5X2	LACC1	Homo sapiens	Q8IV20	Anti Tag CoIP	28514442
Intra	SNX8	Q9Y5X2	POR	Homo sapiens	P16435	Anti Tag CoIP	33961781
Intra	SNX8	Q9Y5X2	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	SNX8	Q9Y5X2	NCK1	Homo sapiens	P16333	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Atrial Tachyarrhythmia With Short Pr Interval	Lown-Ganong-Levine Syndrome Syndrome Of Short P-R Interval, Normal Qrs Complexes, And Supraventricular Tachycardias Lgl Syndrome
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13547	SNX8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SNX8	VGNC	VGNC:65559
Canis familiaris	SNX8	VGNC	VGNC:46644
Bos taurus	SNX8	VGNC	VGNC:35114
Macaca mulatta	SNX8	VGNC	VGNC:77703
Rattus norvegicus	SNX8	RGD	RGD:1305791
Mus musculus	SNX8	MGD	MGI:2443816
Others	SNX8	NCBI