C3a (70-77) TFA
Based on 1 publication(s) in Google Scholar
C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.
For research use only. We do not sell to patients.
- Purity: 99.79%
- Formula: C37H62F3N13O12
- Molecular Weight:937.96
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) C3a (70-77) TFA
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Biological Activity
The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD[1].
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. The cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 937.96
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Formula C37H62F3N13O12
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Color White to off-white
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Synonyms
Complement 3a (70-77) TFA
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Sequence
Ala-Ser-His-Leu-Gly-Leu-Ala-Arg
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Sequence Shortening
ASHLGLAR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
H2O : 100 mg/mL (106.61 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (106.61 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0661 mL | 5.3307 mL | 10.6614 mL | 26.6536 mL |
| 5 mM | 0.2132 mL | 1.0661 mL | 2.1323 mL | 5.3307 mL | |
| 10 mM | 0.1066 mL | 0.5331 mL | 1.0661 mL | 2.6654 mL | |
| 15 mM | 0.0711 mL | 0.3554 mL | 0.7108 mL | 1.7769 mL | |
| 20 mM | 0.0533 mL | 0.2665 mL | 0.5331 mL | 1.3327 mL | |
| 25 mM | 0.0426 mL | 0.2132 mL | 0.4265 mL | 1.0661 mL | |
| 30 mM | 0.0355 mL | 0.1777 mL | 0.3554 mL | 0.8885 mL | |
| 40 mM | 0.0267 mL | 0.1333 mL | 0.2665 mL | 0.6663 mL | |
| 50 mM | 0.0213 mL | 0.1066 mL | 0.2132 mL | 0.5331 mL | |
| 60 mM | 0.0178 mL | 0.0888 mL | 0.1777 mL | 0.4442 mL | |
| 80 mM | 0.0133 mL | 0.0666 mL | 0.1333 mL | 0.3332 mL | |
| 100 mM | 0.0107 mL | 0.0533 mL | 0.1066 mL | 0.2665 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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