TNFRSF13C - TNF receptor superfamily member 13C Gene

Also Known as BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 115650

About TNFRSF13C

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,922,032-41,926,806 (from NCBI)

This gene has 1 transcript (splice variant), 91 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in spleen (RPKM 19.7), lymph node (RPKM 17.1) and 5 other tissues.

Summary

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

TNFRSF13C Products (1)

mRNA	Protein	Name
NM_052945.4	NP_443177.1	tumor necrosis factor receptor superfamily member 13C

TNFRSF13C Protein Structure

BaffR-Tall_bind

0
100
184 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 13C	B cell-activating factor receptor

Recombinant TNFRSF13C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7130	BAFFR/TNFRSF13C Protein, Human	Q96RJ3-1 (M1-G76)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72764	BAFFR/TNFRSF13C Protein, Human (HEK293, His)	Q96RJ3-1 (S7-A71)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78065	BAFFR/TNFRSF13C Protein, Human (Biotinylated, HEK293, His-Avi)	Q96RJ3-1 (S7-A71)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700453	BAFFR/TNFRSF13C Protein, Human (HEK293, hFc-Flag)	Q96RJ3-1 (S7-A71)	≥ 95%, as determined by reducing SDS-PAGE.

TNFRSF13C Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81611	BAFFR Antibody (YA1356)	FC, ELISA	Human
HY-P84740	BAFFR Antibody (YA4437)	WB, FC, ELISA	Human, Rat
HY-P84740A	BAFFR Antibody (YA4437)(PBS only)	WB, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Immunodeficiency, Common Variable, 4	CVID4 Antibody Deficiency Due To Baffr Defect Common Variable Immunodeficiency 4 Immunodeficiency, Variable, Common, Type 4
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Immunodeficiency, Common Variable, 2	CVID2 Antibody Deficiency Due To Taci Defect Hypogammaglobulinemia Due To Taci Deficiency Common Variable Immunodeficiency 2 Immunodeficiency, Variable, Common, Type 2
Primary Agammaglobulinemia	Immunoglobulin Deficiency Antibody Deficiency Syndrome Antibody Antibody Deficiency Gammaglobulin Deficiency Antibody Deficiency With Near-Normal Immunoglobulins Or With Hyperimmunoglobulinaemia Immunoglobulin Deficiency With Near-Normal Immunoglobins Immunoglobulin Deficiency With Hyperimmunoglobulinaemia Antibody Immunodeficiency With Hyperimmunoglobulinaemia Antibody Deficiency With Hyperimmunoglobulinaemia
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Macroglobulinemia	Primary Macroglobulinemia Waldenstrom Macroglobulinemia
Transient Hypogammaglobulinemia Of Infancy	Immunoglobulin Maturational Delay Thi - [Transient Hypogammaglobulinaemia Of Infancy]
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Cd40 Ligand Deficiency	X-Linked Hyper Igm Syndrome Hyperimmunoglobulin M Syndrome Higm1 Hyper-Igm Syndrome Type 1 X-Linked Hyper-Igm Syndrome Xhigm Higmx-1 X-Linked Hyper-Igm Immunodeficiency Hyper-Igm Syndrome 1 Immunodeficiency With Hyper-Igm, Type 1 Hyper-Igm Syndrome Due To Cd40 Ligand Deficiency Hyper-Igm Syndrome Due To Cd40l Deficiency Hyper-Igm Immunodeficiency Syndrome Hyper-Igm Immunodeficiency Syndrome, Type 1
Transient Hypogammaglobulinemia
Trypanosomiasis
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Selective Igg Deficiency Disease	Igg Deficiency Immunoglobin G Subclass Deficiency Selective Deficiency Of Igg Selective Igg Immunodeficiency Selective Immunoglobulin G Deficiency Selective Immunoglobulin G Subclass Deficiency
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Immunodeficiency With Hyper-Igm, Type 4	HIGM4 Hyper-Igm Syndrome Type 4 Immunodeficiency With Hyper-Igm Type 4 Hyper-Igm Syndrome 4 Immunodeficiency With Hyper Igm Type 4 Hyper Igm Syndrome 4 Immunodeficiency, With Hyper Igm, Type 4
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Immunoglobulin Alpha Deficiency	Iga Deficiency Gamma-A-Globulin Deficiency Immunoglobulin A Deficiency
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Immunodeficiency With Hyper-Igm, Type 3	HIGM3 Immunodeficiency With Hyper Igm Type 3 Hyper-Igm Syndrome Type 3 Hyper-Igm Syndrome 3 Hyper-Igm Syndrome Due To Cd40 Deficiency Cd40 Deficiency Type 3 Hyper-Igm Immunodeficiency Hyper Igm Syndrome 3 Immunodeficiency With Hyper-Igm 3 Hyper-Igm Immunodeficiency Type 3 Immunodeficiency, With Hyper Igm, Type 3 Hyper-Igm Immunodeficiency Syndrome, Type 3
Immunodeficiency With Hyper-Igm, Type 1	Immunodeficiency, X-Linked, With Hyper-Igm Hyper Igm Syndrome HIGM1 Xhim Hyper-Igm Syndrome Higm Hyper-Igm Syndrome 1 Immunodeficiency 3 Imd3 Immunodeficiency With Hyper-Igm Immunodeficiency With Hyper Igm Type 1 Ihis X-Linked Hyper Igm Syndrome Hyper-Igm Immunodeficiency, X-Linked Hyper Igm Immunodeficiency, X-Linked Hyper Igm Syndrome 1 X-Linked Immunodeficiency With Hyper-Igm 1 Immunodeficiency, With Hyper Igm Immunodeficiency, With Hyper Igm, Type 1 Hyper-Igm Immunodeficiency Syndrome, Type 1 Hyperimmunoglobulin M Syndrome
Good Syndrome	Immunodeficiency With Thymoma Thymoma-Immunodeficiency Syndrome Thymoma With Hypogammaglobulinemia Thymoma Immunodeficiency
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Lymphoid Interstitial Pneumonia	Lymphocytic Interstitial Pneumonia Lip Disease Lip Diseases LIP Disease Of Lips
Autoimmune Disease Of Exocrine System
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14805	TNFRSF13C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17354	Tnfrsf13c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23808	Tnfrsf13c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TNFRSF13C	VGNC	VGNC:54377
Felis catus	TNFRSF13C	VGNC	VGNC:66405
Bos taurus	TNFRSF13C	VGNC	VGNC:57365
Macaca mulatta	TNFRSF13C	VGNC	VGNC:108067
Mus musculus	TNFRSF13C	MGD	MGI:1919299
Rattus norvegicus	TNFRSF13C	RGD	RGD:1560810
Others	TNFRSF13C	NCBI