PVR - PVR cell adhesion molecule Gene

Also Known as PVS; HVED; CD155; NECL5; TAGE4; Necl-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5817

About PVR

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:44,643,910-44,666,162 (from NCBI)

This gene has 6 transcripts (splice variants), 600 orthologues and 14 paralogues. Ubiquitous expression in adrenal (RPKM 7.2), placenta (RPKM 6.6) and 25 other tissues.

Summary

The protein encoded by this gene is a Transmembrane Glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule Vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

PVR Products (4)

mRNA	Protein	Name
NM_001135768.3	NP_001129240.1	poliovirus receptor isoform beta precursor
NM_001135769.3	NP_001129241.1	poliovirus receptor isoform gamma precursor
NM_001135770.4	NP_001129242.2	poliovirus receptor isoform delta precursor
NM_006505.5	NP_006496.4	poliovirus receptor isoform alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12913096	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19011627	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	16304049	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP IMP: Inferred from mutant phenotype	12913096	GOA
involved in susceptibility to T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	15039383	GOA
involved in susceptibility to natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	12913096	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	16831868	GOA
located in membrane	IDA IDA: Inferred from direct assay	12913096	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PVR Protein Structure

V-set

C2-set_2

0
100
200
300
417 a.a.

Protein Preferred Names	Protein Names
poliovirus receptor	nectin-like protein 5

PVR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PVR	P15151	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	PVR	P15151	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	PVR	P15151	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	PVR	P15151	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	PVR	P15151	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	PVR	P15151	EDDM3B	Homo sapiens	P56851	Validated Y2H	32296183
Intra	PVR	P15151	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	PVR	P15151	SNAP47	Homo sapiens	Q5SQN1	Validated Y2H	32296183
Intra	PVR	P15151	ZDHHC22	Homo sapiens	Q8N966	Validated Y2H	32296183
Intra	PVR	P15151	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
Intra	PVR	P15151	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	PVR	P15151	SLC41A2	Homo sapiens	Q96JW4	Validated Y2H	32296183
Intra	PVR	P15151	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	PVR	P15151	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	PVR	P15151	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
Intra	PVR	P15151	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
Intra	PVR	P15151	TMBIM6	Homo sapiens	P55061	Validated Y2H	32296183
Intra	PVR	P15151	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	PVR	P15151	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	PVR	P15151	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	PVR	P15151	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	PVR	P15151	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	PVR	P15151	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	PVR	P15151	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	PVR	P15151	TMEM276	Homo sapiens	P0DTL5	Validated Y2H	32296183
Intra	PVR	P15151	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	PVR	P15151	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	PVR	P15151	TMEM229B	Homo sapiens	Q8NBD8	Validated Y2H	32296183
Intra	PVR	P15151	BRICD5	Homo sapiens	Q6PL45-2	Validated Y2H	32296183
Intra	PVR	P15151	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	PVR	P15151	AQP10	Homo sapiens	Q96PS8	Validated Y2H	32296183
Intra	PVR	P15151	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	PVR	P15151	TAS2R19	Homo sapiens	P59542	Validated Y2H	32296183
Intra	PVR	P15151	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	PVR	P15151	SYS1	Homo sapiens	Q8N2H4	Validated Y2H	32296183
Intra	PVR	P15151	SYS1	Homo sapiens	Q8N2H4	Y2H Prey Pooling	32296183
Intra	PVR	P15151	TM6SF2	Homo sapiens	Q9BZW4	Validated Y2H	32296183
Intra	PVR	P15151	CD47	Homo sapiens	Q08722-3	Validated Y2H	32296183
Intra	PVR	P15151	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	PVR	P15151	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	PVR	P15151	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	PVR	P15151	KRTAP6-3	Homo sapiens	Q3LI67	Validated Y2H	32296183
Intra	PVR	P15151	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	PVR	P15151	NINJ1	Homo sapiens	Q92982	Y2H Array	32296183
Intra	PVR	P15151	NINJ1	Homo sapiens	Q92982	Validated Y2H	32296183
Intra	PVR	P15151	OLFM4	Homo sapiens	Q6UX06	Validated Y2H	32296183
Intra	PVR	P15151	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	PVR	P15151	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	PVR	P15151	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	PVR	P15151	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	PVR	P15151	TMEM54	Homo sapiens	Q969K7	Validated Y2H	32296183
Intra	PVR	P15151	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	PVR	P15151	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	PVR	P15151	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	PVR	P15151	CD226	Homo sapiens	Q15762	GMS	30591568
Intra	PVR	P15151	TIGIT	Homo sapiens	Q495A1	Protein Array	21982860
Intra	PVR	P15151	HHATL	Homo sapiens	Q9HCP6	Validated Y2H	32296183
Intra	PVR	P15151	PLP2	Homo sapiens	Q04941	Validated Y2H	32296183
Intra	PVR	P15151	TSPO	Homo sapiens	P30536	Validated Y2H	32296183
Intra	PVR	P15151	TMEM65	Homo sapiens	Q6PI78	Validated Y2H	32296183
Intra	PVR	P15151	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	PVR	P15151	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	PVR	P15151	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	PVR	P15151	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	PVR	P15151	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	PVR	P15151	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	PVR	P15151	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	25416956
Intra	PVR	P15151	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	32296183
Intra	PVR	P15151	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	31515488
Intra	PVR	P15151	SLC30A2	Homo sapiens	Q9BRI3	Y2H Prey Pooling	32296183
Intra	PVR	P15151	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	32296183
Intra	PVR	P15151	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	32296183
Intra	PVR	P15151	TMEM79	Homo sapiens	Q9BSE2	Validated Y2H	32296183
Intra	PVR	P15151	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	PVR	P15151	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	PVR	P15151	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183
Intra	PVR	P15151	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183
Intra	PVR	P15151	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PVR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7401	PVR/CD155 Protein, Human (HEK293, Fc)	P15151-1 (W21-N343)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70807	PVR/CD155 Protein, Human (HEK293, His)	NP_006496 (W21-N343)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75614	PVR/CD155 Protein, Human (HEK293)	P15151-1 (W21-N343)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78082	PVR/CD155 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P15151-1 (W21-N343)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78084	PVR/CD155 Protein, Human (Biotinylated, HEK293, His-Avi)	P15151-1 (W21-N343)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78400	PVR/CD155 Protein, Human (HEK293, mFc)	P15151-1 (W21-N343)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78402	PVR/CD155 Protein, Human (HEK293, His-Avi)	P15151-1 (W21-N343)	≥ 95%, as determined by Bis-Tris PAGE.

PVR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81740	Poliovirus Receptor/PVR Antibody (YA1485)	FC, ELISA	Human
HY-P82811	Poliovirus Receptor/PVR Antibody (YA2556)	WB, IP	Human
HY-P84967	CD155 Antibody (YA4659)	ELISA

Related Diseases

Diseases	Alias
Poliomyelitis	Polio Infantile Paralysis
Paralytic Poliomyelitis	Poliomyelitis, Paralytic
Bulbar Polio	Poliomyelitis, Bulbar Bulbar Poliomyelitis
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome	Orofacial Cleft 7 Zlotogora-Ogur Syndrome CLPED1 Ectodermal Dysplasia, Margarita Island Type Ed4 Cleft Lip-Palate-Ectodermal Dysplasia Syndrome Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate Ectodermal Dysplasia 4 Ectodermal Dysplasia Margarita Type Ectodermal Dysplasia, Type 4 Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly Margarita Type Of Ectodermal Dysplasia Zlotogora-Zilberman-Tenenbaum Syndrome Ectd4 Ectodermal Dysplasia 4, Hair/Nail Type EDMI Ectodermal Dysplasia Type 4 Margarita Island Ectodermal Dysplasia Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate Non-Syndromic Orofacial Cleft 7 OFC7 Non-Syndromic Cleft Lip/Palate 7 Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Postpoliomyelitis Syndrome	Postpolio Syndrome Post-Polio Syndrome Post Polio Syndrome Polio Late Effects Post-Polio Muscular Atrophy Post-Polio Sequelae Post-Poliomyelitic Syndrome Postpolio Sequelae Postpoliomyelitic Syndrome Postpoliomyelitis Sequelae
Acute Flaccid Myelitis
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0070A	Liothyronine	Activator	99.82%	Unkown
HY-B0640	Epinastine		98.0%	Unkown
HY-B0640A	Epinastine hydrochloride		99.86%	Unkown
HY-14252A	Milrinone lactate	Inhibitor	98.76%	Unkown
HY-B0640AR	Epinastine hydrochloride (Standard)		/	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16791	Pvr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18105	Nectin2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112352	SU9518		/	Unkown
HY-A0070AS5	Liothyronine-d4		/	Unkown
HY-RS11473	PVR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23231	Pvr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991475	MG-1131		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PVR	RGD	RGD:3813
Felis catus	PVR	VGNC	VGNC:69186
Mus musculus	PVR	MGD	MGI:107741
Canis familiaris	PVR	VGNC	VGNC:82568
Others	PVR	NCBI