IL1RL1 - interleukin 1 receptor like 1 Gene

Also Known as T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9173

About IL1RL1

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,311,563-102,352,356 (from NCBI)

This gene has 9 transcripts (splice variants), 123 orthologues and 10 paralogues. Biased expression in placenta (RPKM 51.1), kidney (RPKM 5.3) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

IL1RL1 Products (3)

mRNA Protein Name
NM_001282408.2 NP_001269337.1 interleukin-1 receptor-like 1 isoform 3
NM_003856.4 NP_003847.2 interleukin-1 receptor-like 1 isoform 2 precursor
NM_016232.5 NP_057316.3 interleukin-1 receptor-like 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables interleukin-33 receptor activity IDA
IDA: Inferred from direct assay
16286016 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8621446 GOA
Biological Process GO Annotation Evidence References Source
involved in interleukin-33-mediated signaling pathway IDA
IDA: Inferred from direct assay
16286016 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL1RL1 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (28 - 103)

Ig_2

Ig_2: Immunoglobulin domain (141 - 201)

Ig_3

Ig_3: Immunoglobulin domain (212 - 307)

TIR

TIR: TIR domain (379 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 556 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-like 1

  • growth stimulation-expressed

IL1RL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IL1RL1 Q01638 CLEC7A Homo sapiens Q9BXN2
Validated Y2H
25416956
Intra
IL1RL1 Q01638 CLEC7A Homo sapiens Q9BXN2
Y2H Array
25416956
Intra
IL1RL1 Q01638 IL33 Homo sapiens O95760
Pull Down
16286016
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL1RL1 Proteins

Cat. No. Product Name Accession Purity
HY-P70615 ST2/IL1RL1 Protein, Human (310a.a, HEK293, His) Q01638-2 (K19-F328) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76090 ST2/IL1RL1 Protein, Human (HEK293) Q01638-2 (K19-F328) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76091 ST2/IL1RL1 Protein, Human (HEK293, Fc) Q01638-2 (K19-F328) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P76093 ST2/IL1RL1 Protein, Human (HEK293, His) Q01638-1 (K19-S328) ≥ 95%, as determined by reducing SDS-PAGE.

IL1RL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811301 IL-1RL1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Chicken Egg Allergy

  • Gallus Gallus Egg Allergy
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Loeffler Syndrome

  • Loeffler'S Pneumonia

  • Loffler'S Syndrome

  • Simple Pulmonary Eosinophilia
Conjunctivitis

  • Madras Eye

  • Adenoviral Conjunctivitis

  • Acute Adenoviral Follicular Conjunctivitis

  • Inclusion Conjunctivitis Of The Adult

  • Swimming-Pool Conjunctivitis

  • Inflammation Of Conjunctiva

  • Ophthalmia

  • Acute Conjunctivitis

  • Eye Catarrh

  • Catarrhal Ophthalmia

  • Koch-Weeks Conjunctivitis
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Childhood-Onset Asthma

  • Childhood Asthma

  • Asthma Childhood
Chronic Asthma
Pneumothorax, Primary Spontaneous

  • Primary Spontaneous Pneumothorax

  • Spontaneous Pneumothorax

  • Familial Spontaneous Pneumothorax

  • PSP

  • Pneumothorax
Intrinsic Asthma

  • Non-Atopic Asthma
Respiratory Allergy

  • Airway Allergy
Bronchial Disease

  • Bronchial Diseases

  • Bronchial Disorders

  • Bronchial Spasm
Parasitic Helminthiasis Infectious Disease

  • Helminthiasis

  • Intestinal Helminthiasis

  • Helminth Infection

  • Helminthosis

  • Worm Infection

  • Worm Infections

  • Helminth Infections

  • Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

  • Parasitic Enteritis

  • Metazoal Dysentery

  • Intestinal Worms Nos
Nasal Cavity Disease

  • Disorder Of Nasal Cavity
Nose Disease

  • Nose Diseases

  • Disorder Of The Nose

  • Nasal Disorder

  • Abnormality Of The Nose
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06725 IL1RL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174607 Human IL33 mRNA / Unkown
HY-RS17312 Il1rl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23767 Il1rl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta IL1RL1 VGNC VGNC:73721
Bos taurus IL1RL1 VGNC VGNC:30134
Felis catus IL1RL1 VGNC VGNC:67768
Rattus norvegicus IL1RL1 RGD RGD:2894
Canis familiaris IL1RL1 VGNC VGNC:41961
Mus musculus IL1RL1 MGD MGI:98427
Others IL1RL1 NCBI