DMTr-LNA-C(Bz)-3-CED-phosphoramidite

Cat. No.: HY-W570891 Purity: 98.70%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a purine nucleoside analog that can be used to synthesize oligonucleotides.

For research use only. We do not sell to patients.

DMTr-LNA-C(Bz)-3-CED-phosphoramidite Chemical Structure

CAS No. : 206055-78-9

Size	Stock	Quantity
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	Get quote	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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Purity & Documentation
References
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Description

DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a purine nucleoside analog that can be used to synthesize oligonucleotides^[1].

In Vitro

DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a locked nucleic acid (LNA) building block, crucial for the synthesis of LNA oligonucleotides.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

861.92

Formula

C₄₇H₅₂N₅O₉P

CAS No.

206055-78-9

Appearance

Solid

Color

White to off-white

SMILES

[H][C@@]12[C@H](N3C(N=C(NC(C4=CC=CC=C4)=O)C=C3)=O)O[C@@]([C@H]2OP(N(C(C)C)C(C)C)OCCC#N)(COC(C5=CC=C(OC)C=C5)(C6=CC=CC=C6)C7=CC=C(OC)C=C7)CO1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (58.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1602 mL	5.8010 mL	11.6020 mL
5 mM	0.2320 mL	1.1602 mL	2.3204 mL
10 mM	0.1160 mL	0.5801 mL	1.1602 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.70%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (261 KB) HNMR (325 KB) CNMR (152 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1602 mL	5.8010 mL	11.6020 mL	29.0050 mL
	5 mM	0.2320 mL	1.1602 mL	2.3204 mL	5.8010 mL
	10 mM	0.1160 mL	0.5801 mL	1.1602 mL	2.9005 mL
	15 mM	0.0773 mL	0.3867 mL	0.7735 mL	1.9337 mL
	20 mM	0.0580 mL	0.2901 mL	0.5801 mL	1.4503 mL
	25 mM	0.0464 mL	0.2320 mL	0.4641 mL	1.1602 mL
	30 mM	0.0387 mL	0.1934 mL	0.3867 mL	0.9668 mL
	40 mM	0.0290 mL	0.1450 mL	0.2901 mL	0.7251 mL
	50 mM	0.0232 mL	0.1160 mL	0.2320 mL	0.5801 mL