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Cat. No.: HY-183542

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DprE1-IN-15

DprE1-IN-15 is a covalent Mycobacterium tuberculosis essential cell wall enzyme DprE1 inhibitor with an IC₅₀ of 0.073 μM. DprE1-IN-15 forms an irreversible covalent adduct with its target enzyme. DprE1-IN-15 shows inhibitory effects against multiple Mycobacterium tuberculosis.

For research use only. We do not sell to patients.

Formula: C₂₀H₂₁F₅N₄O₃Se
Molecular Weight:539.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DprE1-IN-15 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

DprE1-IN-15 (Compound 11c) (30 min) potently inhibits purified Mycobacterium tuberculosis DprE1 with an IC₅₀ of 0.073 μM via covalent adduct formation^[1].
DprE1-IN-15 (7 days) potently inhibits growth of drug-sensitive Mycobacterium tuberculosis H₃₇Rv and extensively drug-resistant TB strains 13946 and 14862, with an MIC of <0.002 μM for all tested strains^[1].
DprE1-IN-15 (0.26-64 μg/mL; 48 h) exhibits no significant cytotoxicity against Vero or HepG2 cells, with an IC₅₀ of >100 μM for both cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Vero, HepG2 cells
Concentration:

0.26-64 μg/mL
Incubation Time:

48 h
Result:

Showed low cytotoxicity, with an IC₅₀ of >100 μM against both Vero and HepG2 cells.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	F
Mice^[1]	50 mg/kg	p.o.	4.77 h	2.00 h	709 ng/mL	3233 ng·h/mL	31.9 %
Mice^[1]	5 mg/kg	i.v.	1.30 h	0.08 h	1593 ng/mL	1008 ng·h/mL	/

In Vivo

DprE1-IN-15 (Compound 11c) (5-50 mg/kg; p.o., i.v.; single dose) exhibits an oral bioavailability of 31.9% in male CD-1 mice, with favorable systemic exposure following both oral and intravenous administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 539.36
Formula C₂₀H₂₁F₅N₄O₃Se
SMILES

O=C1N=C(N2CCN(CC3CCC(F)(F)CC3)CC2)[Se]C4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu Y, et al. Discovery of Potent Benzoselenazinone-Based DprE1 Inhibitors: A Novel Selenium-Containing Scaffold with Superior Anti-TB Activity and Pharmacokinetic Properties. J Med Chem. 2026;69(9):10579-10593. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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