2. PROTAC
  3. Ligands for E3 Ligase
  4. E3 ligase Ligand 40

E3 Ligase Ligand 40 is an E3 ligase ligand and can be used for the synthesis of PROTAC molecules.

For research use only. We do not sell to patients.

E3 ligase Ligand 40

E3 ligase Ligand 40 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

E3 ligase Ligand 40 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

E3 Ligase Ligand 40 is an E3 ligase ligand and can be used for the synthesis of PROTAC molecules[1].

Molecular Weight

290.30

Formula

C13H15FN6O
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(N=C1F)NC)NC2=NN=C(N(C)C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (34.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4447 mL 17.2236 mL 34.4471 mL
5 mM 0.6889 mL 3.4447 mL 6.8894 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4447 mL 17.2236 mL 34.4471 mL 86.1178 mL
5 mM 0.6889 mL 3.4447 mL 6.8894 mL 17.2236 mL
10 mM 0.3445 mL 1.7224 mL 3.4447 mL 8.6118 mL
15 mM 0.2296 mL 1.1482 mL 2.2965 mL 5.7412 mL
20 mM 0.1722 mL 0.8612 mL 1.7224 mL 4.3059 mL
25 mM 0.1378 mL 0.6889 mL 1.3779 mL 3.4447 mL
30 mM 0.1148 mL 0.5741 mL 1.1482 mL 2.8706 mL
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E3 ligase Ligand 40 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 ligase Ligand 40Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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E3 ligase Ligand 40
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