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Cat. No.: HY-10368

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EGFR/VEGFR2-IN-4

EGFR/VEGFR2-IN-4 (Compound 19) is the irreversible inhibitor for EGFR and VEGFR-2 with IC₅₀ of 18.7 nM and 102.3 nM, under the presence of 1 μM ATP.

For research use only. We do not sell to patients.

CAS No.: 870962-74-6
Formula: C₂₉H₂₉N₅O₅
Molecular Weight:527.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

EGFR/VEGFR2-IN-4 Chemical Structure

CAS No.: 870962-74-6

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

EGFR/VEGFR2-IN-4 (Compound 19) is the irreversible inhibitor for EGFR and VEGFR-2 with IC₅₀ of 18.7 nM and 102.3 nM, under the presence of 1 μM ATP^[1].

IC₅₀ & Target

EGFR

18.7 nM (IC₅₀)

VEGFR2

102.3 nM (IC₅₀)

All EGFR Isoforms :

All VEGFR Isoforms :

Chemical Information

CAS No. 870962-74-6
Molecular Weight 527.57
Formula C₂₉H₂₉N₅O₅
SMILES

CCOC(C(NC(/C=C/CN(C)C)=O)=C1)=CC2=C1C(NC(C(C=C3OCC4=CC=CC=C4)=O)=CC3=O)=NC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wissner A, et al., Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2. Bioorg Med Chem. 2007 Jun 1;15(11):3635-48. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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EGFR/VEGFR2-IN-4

All EGFR Isoforms

All VEGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR/VEGFR2-IN-4 Related Classifications

HY-10368 Related Classifications