ERK1/2 inhibitor 9
ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM). ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2.
For research use only. We do not sell to patients.
- Purity: 95.91%
- CAS No.: 2169302-75-2
- Formula: C31H32ClN7O3
- Molecular Weight:586.08
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERK1 |
ERK2 |
Chemical Information
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CAS No. 2169302-75-2
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Appearance Solid
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Molecular Weight 586.08
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Formula C31H32ClN7O3
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Color Off-white to light yellow
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SMILES
O=C(NCCC#CC1=NC=CC(NC2=NC=C(C(NC3=C(NC(C=C)=O)C=CC=C3)=N2)Cl)=C1)OC4CC/C=C\CCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (85.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7063 mL | 8.5313 mL | 17.0625 mL | 42.6563 mL |
| 5 mM | 0.3413 mL | 1.7063 mL | 3.4125 mL | 8.5313 mL | |
| 10 mM | 0.1706 mL | 0.8531 mL | 1.7063 mL | 4.2656 mL | |
| 15 mM | 0.1138 mL | 0.5688 mL | 1.1375 mL | 2.8438 mL | |
| 20 mM | 0.0853 mL | 0.4266 mL | 0.8531 mL | 2.1328 mL | |
| 25 mM | 0.0683 mL | 0.3413 mL | 0.6825 mL | 1.7063 mL | |
| 30 mM | 0.0569 mL | 0.2844 mL | 0.5688 mL | 1.4219 mL | |
| 40 mM | 0.0427 mL | 0.2133 mL | 0.4266 mL | 1.0664 mL | |
| 50 mM | 0.0341 mL | 0.1706 mL | 0.3413 mL | 0.8531 mL | |
| 60 mM | 0.0284 mL | 0.1422 mL | 0.2844 mL | 0.7109 mL | |
| 80 mM | 0.0213 mL | 0.1066 mL | 0.2133 mL | 0.5332 mL |
ERK1/2 inhibitor 9 Related Classifications
HY-153738 Related Classifications
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