Hdac7 - histone deacetylase 7 Gene

Also Known as Hdac7a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84582

About Hdac7

Primary_assembly 7: 128,923,920-128,962,072 reverse strand.mRatBN7.2:CM026980.1

This gene has 6 transcripts (splice variants), 263 orthologues, 12 paralogues and is associated with 3 phenotypes. Biased expression in Thymus (RPKM 193.5), Lung (RPKM 114.3) and 8 other tissues.

Summary

Predicted to enable several functions, including 14-3-3 protein binding activity; protein kinase C binding activity; and transcription corepressor activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of neuron death; and neuron apoptotic process. Predicted to be located in cytosol and nucleus. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC7 (histone deacetylase 7). [provided by Alliance of Genome Resources, Apr 2022]

Hdac7 Products (7)

mRNA Protein Name
XM_006242365.4 XP_006242427.2 histone deacetylase 7 isoform X2
XM_006242364.4 XP_006242426.2 histone deacetylase 7 isoform X1
XM_039080354.1 XP_038936282.1 histone deacetylase 7 isoform X1
XM_039080355.1 XP_038936283.1 histone deacetylase 7 isoform X6
XM_006242367.4 XP_006242429.2 histone deacetylase 7 isoform X5
XM_008765843.3 XP_008764065.1 histone deacetylase 7 isoform X4
XM_006242366.4 XP_006242428.2 histone deacetylase 7 isoform X3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19261284 RGD
involved in neuron apoptotic process IEP
IEP: Inferred from expression pattern
21118817 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
12850547 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac7 Protein Structure

PHA03247

PHA03247: cl33720 (121 - 542)

Arginase_HDAC

Arginase_HDAC: cl17011 (543 - 918)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 975 a.a.
Protein Preferred Names Protein Names

histone deacetylase 7

  • HD7

  • HD7a

  • histone deacetylase 7A

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.96% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-150109 Puzerinostat mesylate Inhibitor 99.45% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-N6735 Apicidin Inhibitor 99.87% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-N5084 Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside Inhibitor 98.92% Unkown
HY-169259 HDAC9-IN-1 Inhibitor 95.13% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-180224 HDAC6-IN-70 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-180811 ALK/HDAC-IN-2 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-178104 HDAC-IN-93 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-179227 HDAC6 ligand-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac7 NCBI NCBI:51564