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Cat. No.: HY-108190

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Tuberactinomycin A

Tuberactinomycin A is a basic cyclic peptide antibiotic and a group I intron RNA splicing inhibitor, with an IC₅₀ of 10 μM against the G-binding site of bacteriophage T4 group I intron RNA. Tuberactinomycin A exerts antibacterial effects by acting on the initiation and elongation steps of bacterial bacteria ribosomes to inhibit prokaryotic protein synthesis. Tuberactinomycin A competes with guanosine cofactors for binding to the G-binding site of group I intron RNA, forms electrostatic interactions with the RNA backbone, and inhibits the self-splicing of bacteriophage T4 td and sunY group I introns, and its inhibitory activity depends on Mg²⁺ concentration. Tuberactinomycin A can be used in studies related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 33103-21-8
Formula: C₂₅H₄₃N₁₃O₁₁
Molecular Weight:701.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tuberactinomycin A Chemical Structure

CAS No.: 33103-21-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

Tuberactinomycin A (10 μM) potently inhibits self-splicing of the phage T4 td intron and sunY intron with 50% inhibition at 10 μM, making it far more active than earlier identified competitive splicing inhibitors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 33103-21-8
Molecular Weight 701.70
Formula C₂₅H₄₃N₁₃O₁₁
SMILES

O=C(N)NC=C1NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CC(N)C(O)CCN)CNC(=O)C(NC1=O)C2NC(=NC(O)C2)N)CO)CO
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wank H, et al. Peptide antibiotics of the tuberactinomycin family as inhibitors of group I intron RNA splicing. Journal of molecular biology. 1994 Mar 04;236(4):1001-10.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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