XAT-13
XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases.
For research use only. We do not sell to patients.
- CAS No.: 3107904-58-2
- Formula: C20H16O5
- Molecular Weight:336.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
MRGPRX2 |
In Vitro
XAT-13 (up to 100 μmol/L) shows no cytotoxicity in LAD2 cells[1].
XAT-13 (25-100 μmol/L) inhibits C48/80-induced β-hexosaminidase release from LAD2 cells in a dose-dependent manner, with an IC50 of 57.27 ± 0.13 μmol/L, and is more potent than Imperatorin (HY-N0285)[1].
XAT-13 (25-100 μmol/L) dose-dependently inhibits C48/80-induced intracellular calcium influx in MRGPRX2-HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C48/80-induced local allergy[1]
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Dosage:4, 8, 16 mg/kg
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Administration:p.o.
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Result:Attenuated the hind paws thickness.
Resulted in statistically significant differences in serum histamine levels.
Chemical Information
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CAS No. 3107904-58-2
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Molecular Weight 336.34
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Formula C20H16O5
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SMILES
O=C1OC2=C(OCCCOC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XAT-13 Related Classifications
HY-181891 Related Classifications
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