ZFYVE19 - zinc finger FYVE-type containing 19 Gene

Also Known as ANCHR; PFIC9; MPFYVE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84936

About ZFYVE19

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,807,089-40,815,084 (from NCBI)

This gene has 16 transcripts (splice variants), 193 orthologues, 13 paralogues and is associated with 2 phenotypes. Ubiquitous expression in duodenum (RPKM 6.2), small intestine (RPKM 6.1) and 25 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity. Involved in abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Located in centrosome; cleavage furrow; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

ZFYVE19 Products (4)

mRNA Protein Name
NM_001077268.2 NP_001070736.1 abscission/NoCut checkpoint regulator isoform 1
NM_001258420.2 NP_001245349.1 abscission/NoCut checkpoint regulator isoform 2
NM_001258421.2 NP_001245350.1 abscission/NoCut checkpoint regulator isoform 4
NM_032850.5 NP_116239.3 abscission/NoCut checkpoint regulator isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
24814515 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in abscission IMP
IMP: Inferred from mutant phenotype
24814515 GOA
involved in mitotic cytokinesis checkpoint signaling IMP
IMP: Inferred from mutant phenotype
24814515 GOA
involved in negative regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
24814515 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in centrosome IDA
IDA: Inferred from direct assay
24814515 GOA
located in cleavage furrow IDA
IDA: Inferred from direct assay
24814515 GOA
located in midbody IDA
IDA: Inferred from direct assay
24814515 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE19 Protein Structure

FYVE

FYVE: FYVE zinc finger (78 - 133)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
Protein Preferred Names Protein Names

abscission/NoCut checkpoint regulator

  • MLL partner containing FYVE domain

ZFYVE19 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
ZFYVE19 Q96K21 CAPN7 Homo sapiens Q7Z479
Y2H Prey Pooling
25416956
Intra
ZFYVE19 Q96K21 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
ZFYVE19 Q96K21 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
ZFYVE19 Q96K21 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
ZFYVE19 Q96K21 VPS4B Homo sapiens O75351
Y2H Array
31515488
Intra
ZFYVE19 Q96K21 VPS4B Homo sapiens O75351
Validated Y2H
25416956
Intra
ZFYVE19 Q96K21 VPS4B Homo sapiens O75351
Y2H Array
25416956
Intra
ZFYVE19 Q96K21 VPS4B Homo sapiens O75351
Y2H Prey Pooling
25416956
Intra
ZFYVE19 Q96K21 MITD1 Homo sapiens Q8WV92
Y2H Prey Pooling
25416956
Intra
ZFYVE19 Q96K21 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
ZFYVE19 Q96K21 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
ZFYVE19 Q96K21 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
ZFYVE19 Q96K21 HTT Homo sapiens P42858
Y2H
17500595
Intra
ZFYVE19 Q96K21 DPY30 Homo sapiens Q9C005
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cholestasis, Progressive Familial Intrahepatic, 9

  • PFIC9
Ileocolitis

  • Iieocolitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS16057 ZFYVE19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZFYVE19 VGNC VGNC:67239
Macaca mulatta ZFYVE19 VGNC VGNC:99348
Bos taurus ZFYVE19 VGNC VGNC:37175
Rattus norvegicus ZFYVE19 RGD RGD:1561576
Mus musculus ZFYVE19 MGD MGI:1919258
Canis familiaris ZFYVE19 VGNC VGNC:48624
Others ZFYVE19 NCBI