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VPS4B - vacuolar protein sorting 4 homolog B Gene

Also Known as MIG1; SKD1; SKD1B; VPS4-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9525

About VPS4B

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,389,190-63,422,476 (from NCBI)

This gene has 7 transcripts (splice variants), 263 orthologues, 9 paralogues and is associated with 1 phenotype. Ubiquitous expression in esophagus (RPKM 35.7), colon (RPKM 23.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each Other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the Other resides on chromosome 16. [provided by RefSeq, Jul 2008]

VPS4B Products (1)

mRNA	Protein	Name
NM_004869.4	NP_004860.2	vacuolar protein sorting-associated protein 4B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	11563910	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	16193069	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11563910	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16193069	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18687924	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ESCRT III complex disassembly	IDA IDA: Inferred from direct assay	18687924	GOA
acts upstream of or within endosomal transport	IDA IDA: Inferred from direct assay	11563910	GOA
involved in endosome to lysosome transport via multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	15024011	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in negative regulation of exosomal secretion	IMP IMP: Inferred from mutant phenotype	24105262	GOA
involved in nucleus organization	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in positive regulation of centriole elongation	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in positive regulation of exosomal secretion	IMP IMP: Inferred from mutant phenotype	22660413	GOA
involved in protein depolymerization	IDA IDA: Inferred from direct assay	18687924	GOA
involved in regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in response to lipid	IDA IDA: Inferred from direct assay	16757520	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	22547407	GOA
involved in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	22547407	GOA
involved in viral budding from plasma membrane	IMP IMP: Inferred from mutant phenotype	14505570	GOA
involved in viral budding via host ESCRT complex	IGI IGI: Inferred from genetic interaction	24107264	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Flemming body	IDA IDA: Inferred from direct assay	20616062	GOA
located in centrosome	IDA IDA: Inferred from direct assay	20616062	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16757520	GOA
located in endosome	IDA IDA: Inferred from direct assay	11563910	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	16757520	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16757520	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	20616062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS4B Protein Structure

MIT

AAA

Vps4_C

0
100
200
300
400
444 a.a.

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 4B	cell migration-inducing 1

VPS4B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS4B	O75351	ZFYVE19	Homo sapiens	Q96K21-3	Y2H Array	25416956
Intra	VPS4B	O75351	CHMP1A	Homo sapiens	Q9HD42	Validated Y2H	32296183
Intra	VPS4B	O75351	CHMP1A	Homo sapiens	Q9HD42	Y2H Prey Pooling	32296183
Intra	VPS4B	O75351	CHMP1A	Homo sapiens	Q9HD42	Y2H Array	32296183
Intra	VPS4B	O75351	CHMP2B	Homo sapiens	Q9UQN3-1	NMR	17928862
Intra	VPS4B	O75351	CHMP2B	Homo sapiens	Q9UQN3-1	SPR	17928862
Intra	VPS4B	O75351	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	VPS4B	O75351	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	VPS4B	O75351	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	VPS4B	O75351	ZFYVE19	Homo sapiens	Q96K21	Validated Y2H	32296183
Intra	VPS4B	O75351	ZFYVE19	Homo sapiens	Q96K21	Y2H Array	32296183
Intra	VPS4B	O75351	ZFYVE19	Homo sapiens	Q96K21	Y2H Prey Pooling	32296183
Intra	VPS4B	O75351	KATNAL1	Homo sapiens	Q9BW62	Y2H Prey Pooling	32296183
Intra	VPS4B	O75351	KATNAL1	Homo sapiens	Q9BW62	Validated Y2H	32296183
Intra	VPS4B	O75351	KATNAL1	Homo sapiens	Q9BW62	Y2H Array	32296183
Intra	VPS4B	O75351	CHMP5	Homo sapiens	Q9NZZ3	Validated Y2H	25416956
Intra	VPS4B	O75351	CHMP5	Homo sapiens	Q9NZZ3	Y2H Prey Pooling	32296183
Intra	VPS4B	O75351	CHMP5	Homo sapiens	Q9NZZ3	Y2H Array	32296183
Intra	VPS4B	O75351	CHMP5	Homo sapiens	Q9NZZ3	Validated Y2H	32296183
Intra	VPS4B	O75351	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	VPS4B	O75351	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	VPS4B	O75351	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dentin Dysplasia, Type I	Radicular Dentin Dysplasia DTDP1 Rootless Teeth Dentin Dysplasia Type I Dd-I Dentin Dysplasia Shields Type I Dentin Dysplasia, Shields Type I Dentin Dysplasia, Type I, With Microdontia And Misshapen Teeth Dentin Dysplasia, Type 1 Atypical Dentin Dysplasia Due To Smoc2 Deficiency Dentin Dysplasia Type 1 With Microdontia And Shape Anomalies Dentin Dysplasia, Radicular Dentin Dysplasia 1 Dentin Dysplasia 1, With Extreme Microdontia And Misshapen Teeth DTDP1-MMT Dentin Dysplasia, Type I, With Extreme Microdontia And Misshapen Teeth Dysplasia, Dentin, Type I
Dentin Dysplasia	Dentinal Dysplasia Dd Dysplasia, Dentin Shell Teeth
Meckel Syndrome, Type 6	Meckel Syndrome 6 MKS6 Meckel-Gruber Syndrome, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123872	MSC1094308	Inhibitor	99.89%	Unkown
HY-RS15694	VPS4B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20516	Vps4b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27025	Vps4b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VPS4B	RGD	RGD:1305969
Bos taurus	VPS4B	VGNC	VGNC:36825
Canis familiaris	VPS4B	VGNC	VGNC:48293
Felis catus	VPS4B	VGNC	VGNC:66970
Mus musculus	VPS4B	MGD	MGI:1100499
Macaca mulatta	VPS4B	VGNC	VGNC:78555
Others	VPS4B	NCBI