2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. FLT3-IN-19

FLT3-IN-19 (Comp 50) is a potent and selective FLT3 inhibitor with IC50 of 0.213 nM. FLT3-IN-19 can be used in AML disease research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

FLT3-IN-19

FLT3-IN-19 Chemische Struktur

CAS. Nr. : 2237234-48-7

Größe Preis Verfügbarkeit Menge
5 mg Auf Lager
10 mg Auf Lager
25 mg Auf Lager
50 mg Auf Lager
100 mg   Angebot einholen  
200 mg   Angebot einholen  

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 Customer Validation

FLT3-IN-19 Related Antibodies

Top Publications Citing Use of Products

  • Biologische Aktivität

  • Reinheit & Dokumentation

  • Verweise

  • Kundenbewertung

Beschreibung

FLT3-IN-19 (Comp 50) is a potent and selective FLT3 inhibitor with IC50 of 0.213 nM. FLT3-IN-19 can be used in AML disease research[1].

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
0.334 μM
Compound: 50
Growth inhibition of human HL60 cells expressing low levels of FLT3 after 72 hrs by Cell-Titer Glo assay
Growth inhibition of human HL60 cells expressing low levels of FLT3 after 72 hrs by Cell-Titer Glo assay
[PMID: 29894944]
K562 IC50
0.235 μM
Compound: 50
Growth inhibition of FLT3 null human K562 cells after 72 hrs by Cell-Titer Glo assay
Growth inhibition of FLT3 null human K562 cells after 72 hrs by Cell-Titer Glo assay
[PMID: 29894944]
MOLM-13 IC50
0.039 μM
Compound: 50
Growth inhibition of human MOLM13 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
Growth inhibition of human MOLM13 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
[PMID: 29894944]
MV4-11 IC50
0.016 μM
Compound: 50
Growth inhibition of human MV4-11 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
Growth inhibition of human MV4-11 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
[PMID: 29894944]
Molekulargewicht

418.49

Formel

C22H26N8O
CAS. Nr.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=NNC=C1NC2=NC(C)=NC3=C2CCC3)NC4=CC=C(N5CCNCC5)C=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 5 mg/mL (11.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3895 mL 11.9477 mL 23.8954 mL
5 mM 0.4779 mL 2.3895 mL 4.7791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3895 mL 11.9477 mL 23.8954 mL 59.7386 mL
5 mM 0.4779 mL 2.3895 mL 4.7791 mL 11.9477 mL
10 mM 0.2390 mL 1.1948 mL 2.3895 mL 5.9739 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

FLT3-IN-19 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3-IN-192237234-48-7FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Online-Anfrage

Your information is safe with us. * Required Fields.

Produktname

  

Requested Quantity *

Name des Antragstellers *

 

Anrede

E-Mail-Addresse *

 

Telefonnummer *

Department

 

Name der Organisation *

City

Bundesland

Country or Region *

      

Bemerkungen

Massenanfrage

Inquiry Information

Produktname:
FLT3-IN-19
Art. -Nr.:
HY-153473
Menge:
MCE Japan Authorized Agent:

Kundenbewertung

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Produktname

  

Lot #

Name des Antragstellers *

 

E-Mail-Addresse *

Telefonnummer

 

Department *

Name der Organisation *

 

Country or Region *

Bemerkungen

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.