Fmoc-NH-PEG12-CH2CH2COOH

Name: Fmoc-NH-PEG12-CH2CH2COOH
Brand: MedChemExpress
SKU: HY-135821
Rating: 4.5 (0 reviews)

製品番号: HY-135821 純度: 99.96%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Fmoc-NH-PEG12-CH2CH2COOH 構造式

CAS 番号 : 1952360-91-6

容量	価格（税別）	在庫状況	数量
250 mg	$31	在庫あり	Estimated Time of Arrival: December 31
1 g	$123	在庫あり	Estimated Time of Arrival: December 31
5 g	$540	在庫あり	Estimated Time of Arrival: December 31
10 g	$1065	在庫あり	Estimated Time of Arrival: December 31
25 g	$2120	在庫あり	Estimated Time of Arrival: December 31
100 g	$7020	在庫あり	Estimated Time of Arrival: December 31
> 100 g		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

PROTAC Linkers アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

839.97

分子式

C₄₂H₆₅NO₁₆

CAS 番号

1952360-91-6

Appearance

Liquid (Density: 1.175±0.06 g/cm³)

Color

Light yellow to light brown

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (119.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1905 mL	5.9526 mL	11.9052 mL
5 mM	0.2381 mL	1.1905 mL	2.3810 mL
10 mM	0.1191 mL	0.5953 mL	1.1905 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.96%

Select Batch:

データシート (265 KB) SDS (393 KB)

COA (239 KB) HNMR (134 KB) RP-HPLC (241 KB) LCMS (327 KB)

取扱説明書 (2659 KB)

参考文献

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1905 mL	5.9526 mL	11.9052 mL	29.7630 mL
	5 mM	0.2381 mL	1.1905 mL	2.3810 mL	5.9526 mL
	10 mM	0.1191 mL	0.5953 mL	1.1905 mL	2.9763 mL
	15 mM	0.0794 mL	0.3968 mL	0.7937 mL	1.9842 mL
	20 mM	0.0595 mL	0.2976 mL	0.5953 mL	1.4881 mL
	25 mM	0.0476 mL	0.2381 mL	0.4762 mL	1.1905 mL
	30 mM	0.0397 mL	0.1984 mL	0.3968 mL	0.9921 mL
	40 mM	0.0298 mL	0.1488 mL	0.2976 mL	0.7441 mL
	50 mM	0.0238 mL	0.1191 mL	0.2381 mL	0.5953 mL
	60 mM	0.0198 mL	0.0992 mL	0.1984 mL	0.4960 mL
	80 mM	0.0149 mL	0.0744 mL	0.1488 mL	0.3720 mL
	100 mM	0.0119 mL	0.0595 mL	0.1191 mL	0.2976 mL