Fmoc-Val-Ala-aminomethyl acetate

Cat. No.: HY-156813 Purity: 96.20%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Fmoc-Val-Ala-aminomethyl acetate (Compound 58b) is an ADC Linker, and can be used for synthesis of ADCs.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Fmoc-Val-Ala-aminomethyl acetate 화학구조

CAS No. : 2505045-86-1

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	견적 받기
10 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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•Related Proteins:

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Fmoc-Val-Ala-aminomethyl acetate (Compound 58b) is an ADC Linker, and can be used for synthesis of ADCs^[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

481.54

화학식

C₂₆H₃₁N₃O₆

CAS No.

2505045-86-1

Appearance

Solid

Color

White to off-white

SMILES

CC(OCNC([C@H](C)NC([C@H](C(C)C)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O)=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

DMSO : 50 mg/mL (103.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0767 mL	10.3834 mL	20.7667 mL
5 mM	0.4153 mL	2.0767 mL	4.1533 mL
10 mM	0.2077 mL	1.0383 mL	2.0767 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 97.08%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (248 KB) HNMR (237 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Charng-Sheng TSAI, et al. Antibody drug conjugates. Patent. WO2023125530

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0767 mL	10.3834 mL	20.7667 mL	51.9168 mL
	5 mM	0.4153 mL	2.0767 mL	4.1533 mL	10.3834 mL
	10 mM	0.2077 mL	1.0383 mL	2.0767 mL	5.1917 mL
	15 mM	0.1384 mL	0.6922 mL	1.3844 mL	3.4611 mL
	20 mM	0.1038 mL	0.5192 mL	1.0383 mL	2.5958 mL
	25 mM	0.0831 mL	0.4153 mL	0.8307 mL	2.0767 mL
	30 mM	0.0692 mL	0.3461 mL	0.6922 mL	1.7306 mL
	40 mM	0.0519 mL	0.2596 mL	0.5192 mL	1.2979 mL
	50 mM	0.0415 mL	0.2077 mL	0.4153 mL	1.0383 mL
	60 mM	0.0346 mL	0.1731 mL	0.3461 mL	0.8653 mL
	80 mM	0.0260 mL	0.1298 mL	0.2596 mL	0.6490 mL
	100 mM	0.0208 mL	0.1038 mL	0.2077 mL	0.5192 mL