6-Formylpterin
Based on 1 Customer Validation
6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.0%
- No. CAS: 712-30-1
- Fòrmula: C7H5N5O2
- Peso molecular:191.15
-
Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-124004
Acetyl-6-formylpterin -
HY-B0219
Allopurinol -
HY-N0196
Baicalein -
HY-113978R
6-Formylpterin (Standard) -
HY-N0196R
Baicalein (Standard) -
HY-B0219R
Allopurinol (Standard) -
HY-128442
Phenyl sulfate -
HY-19657
Oxypurinol -
HY-128442R
Phenyl sulfate (Standard) -
HY-133966
6α-Hydroxy-5α-cholestane -
HY-118149A
(±)9-HpODE -
HY-W144308
Tetrachlorohydroquinone
Actividad biológica
Descripciòn
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
1.63 μM
Compound: 6-FP
|
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
|
[PMID: 37638616] |
In Vitro
6-Formylpterin (2 mM) generats intracellular ROS in HL-60 cells[1].
6-Formylpterin (0.5, 1, and 2 mM, 3 h) increases intracellular H2O2, which induces apoptosis in HL-60 cells and Jurkat cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HL-60 cells, Jurkat cells
-
Concentration:0.5, 1, and 2 mM
-
Incubation Time:3 h
-
Result:Induced apoptosis in HL-60 cells[1].
Inhibited Fas-mediated apoptosis in Jurkat cells in 0.5 mM[1].
Chemical Information
-
No. CAS 712-30-1
-
Appearance Solid
-
Peso molecular 191.15
-
Fòrmula C7H5N5O2
-
Color Yellow to brown
-
SMILES
O=CC1=CN=C2N=C(N)NC(C2=N1)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
In Vitro:
H2O : 33.33 mg/mL (174.37 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)
1 M NaOH : 5 mg/mL (26.16 mM; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (272 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1 M NaOH / H2O | 1 mM | 5.2315 mL | 26.1575 mL | 52.3149 mL | 130.7873 mL |
| 5 mM | 1.0463 mL | 5.2315 mL | 10.4630 mL | 26.1575 mL | |
| 10 mM | 0.5231 mL | 2.6157 mL | 5.2315 mL | 13.0787 mL | |
| 15 mM | 0.3488 mL | 1.7438 mL | 3.4877 mL | 8.7192 mL | |
| 20 mM | 0.2616 mL | 1.3079 mL | 2.6157 mL | 6.5394 mL | |
| 25 mM | 0.2093 mL | 1.0463 mL | 2.0926 mL | 5.2315 mL | |
| H2O | 30 mM | 0.1744 mL | 0.8719 mL | 1.7438 mL | 4.3596 mL |
| 40 mM | 0.1308 mL | 0.6539 mL | 1.3079 mL | 3.2697 mL | |
| 50 mM | 0.1046 mL | 0.5231 mL | 1.0463 mL | 2.6157 mL | |
| 60 mM | 0.0872 mL | 0.4360 mL | 0.8719 mL | 2.1798 mL | |
| 80 mM | 0.0654 mL | 0.3270 mL | 0.6539 mL | 1.6348 mL | |
| 100 mM | 0.0523 mL | 0.2616 mL | 0.5231 mL | 1.3079 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
6-Formylpterin Related Classifications
HY-113978 Related Classifications
Powered by Bioz