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Cat. No.: HY-133966

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6α-Hydroxy-5α-cholestane

Name: 6α-Hydroxy-5α-cholestane
Brand: MedChemExpress
SKU: HY-133966
Price: 220.00 USD
Availability: PreOrder

(Synonyms: 5α-Cholestane-3β,6α-diol)

6α-Hydroxy-5α-cholestane (5α-Cholestane-3β,6α-diol) is an oxysterol that promotes the production of superoxide anions in SK-N-BE cells at concentrations of 50 μM and 100 μM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 95.8%
CAS No.: 41083-73-2
화학식: C₂₇H₄₈O₂
분자량:404.67

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

6α-Hydroxy-5α-cholestane Chemical Structure

CAS No.: 41083-73-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
Chemical Information
순도&문서
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Calculators
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Classifications
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Biological Activity

제품 설명

6α-Hydroxy-5α-cholestane (5α-Cholestane-3β,6α-diol) is an oxysterol that promotes the production of superoxide anions in SK-N-BE cells at concentrations of 50 μM and 100 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	8.5 μM Compound: 2	Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to endoplasmic reticulum and plasma membrane after 24 hrs by fluorescence microscopic analysis Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to endoplasmic reticulum and plasma membrane after 24 hrs by fluorescence microscopic analysis	[PMID: 23830695]
HT-29	IC₅₀	24.4 μM Compound: 23	Cytotoxicity against human HT-29 cells after 48 hrs by Alamar blue assay Cytotoxicity against human HT-29 cells after 48 hrs by Alamar blue assay	[PMID: 20931970]

Chemical Information

CAS No. 41083-73-2
Appearance Solid
분자량 404.67
화학식 C₂₇H₄₈O₂
Color White to off-white
SMILES

C[C@@]12[C@]3([H])[C@](C[C@@H]([C@@]1([H])C[C@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C
Synonyms

5α-Cholestane-3β,6α-diol
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zarrouk, et al. Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3). Steroids 99(Pt B), 238-247 (2015). [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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6α-Hydroxy-5α-cholestane

3β,5α,6β-Trihydroxycholestane

9,10-Anthracenediyl-bis(methylene)dimalonic acid

Peroxynitrite sodium

Tetrachlorohydroquinone

CYPMPO

Phenyl sulfate

6-Formylpterin

Tetrachlorohydroquinone (Standard)

S-Allylmercapturic acid

3,4-Dimethoxycinnamic acid

Phenyl sulfate (Standard)

S-Phenylsulfonylcysteine

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

6α-Hydroxy-5α-cholestane

3β,5α,6β-Trihydroxycholestane

9,10-Anthracenediyl-bis(methylene)dimalonic acid

Peroxynitrite sodium

Tetrachlorohydroquinone

CYPMPO

Phenyl sulfate

6-Formylpterin

Tetrachlorohydroquinone (Standard)

S-Allylmercapturic acid

3,4-Dimethoxycinnamic acid

Phenyl sulfate (Standard)

S-Phenylsulfonylcysteine

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

6α-Hydroxy-5α-cholestane Related Classifications

HY-133966 Related Classifications

Bioz