Anticancer agent 210
Anticancer agent 210 (Compound 7a) is a Gefitinib (HY-50895) derivative. Anticancer agent 210 inhibits proliferation, migration and colony formation of cancer cells. Anticancer agent 210 induces apoptosis in cells H1299.
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- No. CAS: 3052009-28-3
- Fòrmula: C31H31BrFN7O3
- Peso molecular:648.53
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Almacenamiento:
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Descripciòn
In Vitro
Anticancer agent 210 (0-32 μM, 48 h) inhibits proliferation of lung cancer cells NCI-H1299, A549, NCI-H1437, with IC50s of 3.94, 3.16 and 1.84 μM, respectively[1].
Anticancer agent 210 (2-16 μM, 48 h) exhibits slightly cytotoxicity in normal hepatocytes L02, with IC50 of 18.87 μM, and a survival rate >60%[1].
Anticancer agent 210 (4-16 μM, 48 h) induces apoptosis of non-small cell lung cancer cells through Bcl-2/caspase3/PARP pathway, inhibits NSCLC cell migration through suppression of MMP9 protein expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H1299, A549, NCI-H1437
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Concentration:0-32 μM
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Incubation Time:48 h
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Result:Inhibited cell proliferation.
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Cell Line:NCI-H1299
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Concentration:4-16 μM
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Incubation Time:48 h
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Result:Inhibited expressions of Bcl-2, caspase9 and MMP9, upregulated levels of cleaved caspase 3 and PARP.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3052009-28-3
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Peso molecular 648.53
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Fòrmula C31H31BrFN7O3
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SMILES
COC(C=C(N=CN=C1NC2=CC(C3=CN(CC4=C(Br)C=CC(F)=C4)N=N3)=CC=C2)C1=C5)=C5OCCCN6CCOCC6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 210 Related Classifications
HY-162481 Related Classifications
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