CJ-17493
Based on 1 publication(s) in Google Scholar
CJ-17493 is a neurokinin-1 (NK1) receptor antagonist, with a Ki of 0.2 nM. CJ-17493 shows moderate affinity for the verapamil-binding site of L-type Ca2+ channels (IC50 = 164 nM) and site 2 of sodium channels (IC50 = 48 nM). CJ-17493 can be used for the study of neurological diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 225655-10-7
- Fòrmula: C24H29F3N2O2
- Peso molecular:434.49
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CJ-17493
More
Actividad biológica
Descripciòn
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| IM-9 | IC50 |
<0.1 nM
Compound: (+)-1, CJ-17493
|
Displacement of [3H]spiperone from NK1 receptor in human IM9 cells
Displacement of [3H]spiperone from NK1 receptor in human IM9 cells
|
[PMID: 18640044] |
Chemical Information
-
No. CAS 225655-10-7
-
Peso molecular 434.49
-
Fòrmula C24H29F3N2O2
-
SMILES
FC(F)(F)[C@@](OCC1)(C)C(C1=C2)=CC(CN[C@@H]3[C@H](C4=CC=CC=C4)NCCC3)=C2OC
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Pharmaceuticals (Basel)
YM155 Inhibition of Survivin Enhances Carboplatin Efficacy in Metastatic Castration-Resistant Prostate Cancer. [Abstract]2025 Nov 18;18(11):1752. PMID: 41304997
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CJ-17493 Related Classifications
HY-10050 Related Classifications
Powered by Bioz