225655-10-7
225655-10-7
Chemical Structure
CJ-17493
- CAS No.: 225655-10-7
- Formula:C24H29F3N2O2
- Molecular Weight:434.49
IUPAC Name: (2S,3S)-N-(((R)-6-methoxy-1-methyl-1-(trifluoromethyl)isochroman-7-yl)methyl)-2-phenylpiperidin-3-amine
InChIKey: ODEBBNRINYMIRX-ACIOBRDBSA-N
SMILES: FC(F)(F)[C@@](OCC1)(C)C(C1=C2)=CC(CN[C@@H]3[C@H](C4=CC=CC=C4)NCCC3)=C2OC
Biological Activity: CJ-17493 is a neurokinin-1 (NK1) receptor antagonist, with a Ki of 0.2 nM. CJ-17493 shows moderate affinity for the verapamil-binding site of L-type Ca2+ channels (IC50 = 164 nM) and site 2 of sodium channels (IC50 = 48 nM). CJ-17493 can be used for the study of neurological diseases[1].
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CJ-17493 | CJ-17493 is a neurokinin-1 (NK1) receptor antagonist, with a Ki of 0.2 nM. CJ-17493 shows moderate affinity for the verapamil-binding site of L-type Ca2+ channels (IC50 = 164 nM) and site 2 of sodium channels (IC50 = 48 nM). CJ-17493 can be used for the study of neurological diseases. | |||||||||||||||||||||
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