Flutolanil
Based on 1 Customer Validation
Flutolanil is a succinate dehydrogenase complex inhibitor and fungicide. Flutolanil blocks electron transfer between the redox center of succinate dehydrogenase and coenzyme Q, inhibits mycelial oxygen consumption, and suppresses mycelial growth. Flutolanil induces acute and sublethal toxicity in zebrafish at different life stages. Flutolanil can be used in studies on plant disease control.
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- Pureza: 99.44%
- No. CAS: 66332-96-5
- Fòrmula: C17H16F3NO2
- Peso molecular:323.31
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Flutolanil (0.003-10 μM; 1 hour) potently inhibits mycelial oxygen consumption of Rhizoctonia solani. After 1 hour of incubation, the inhibition rate reaches 45% at 0.003 μM and 71% at 10 μM[2].
Flutolanil (10 μM) selectively inhibits the activities of complex II-related enzymes (succinate-cytochrome c reductase, succinate-Co Q reductase, succinate-DPIP reductase) in mitochondria of Rhizoctonia solani[2].
Flutolanil (0.1-10 μM) inhibits the activities of succinate-DPIP reductase and succinate-Co Q reductase in mitochondria of Rhizoctonia solani, with an IC50 of 0.5 μM for succinate-DPIP reductase[2].
Flutolanil (10 μM) completely inhibits mycelial growth of Rhizoctonia solani and Corticium rolfsii, but shows only extremely weak or even no inhibitory effect on the growth of Rhizopus chinensis, Rosellinia necatrix and Pyricularia oryzae[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Flutolanil (continuous waterborne exposure; 96 h) exhibits acute aquatic toxicity in 72 h-old zebrafish larvae, with an LC50 of 4.09 mg/L[1].
Flutolanil (continuous waterborne exposure; 96 h) exhibits acute aquatic toxicity to 12-hour-old zebrafish larvae, with an LC50 of 3.91 mg/L[1].
Flutolanil (continuous water exposure; 96 h) exhibits acute aquatic toxicity to adult zebrafish, with an LC50 of 2.70 mg/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Zebrafish (embryo stage)[1]
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Dosage:1.50 mg/L, 1.80 mg/L, 2.16 mg/L, 2.59 mg/L, 3.10 mg/L
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Administration:aqueous exposure; continuous; 11 days
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Result:Determined 96-hour LC50 as 5.47 mg/L.
Reduced spontaneous movement at 24 hpf significantly at ≥2.16 mg/L.
Reduced heartbeat at 48 hpf significantly at ≥2.59 mg/L.
Reduced hatching rate at 72 hpf significantly at ≥1.80 mg/L.
Reduced hatching rate at 96 hpf significantly at ≥2.59 mg/L.
Reduced body length of hatched larvae at 11 days significantly to 386.83 mm (93.88% of control) at 2.16 mg/L.
Caused teratogenic effects including pericardial edema, yolk sac edema, development lag, abnormal melanocyte development, and abnormal tail development.
Increased cumulative mortality visibly.
Chemical Information
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No. CAS 66332-96-5
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Appearance Solid
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Peso molecular 323.31
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Fòrmula C17H16F3NO2
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Color White to off-white
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SMILES
O=C(C1=C(C(F)(F)F)C=CC=C1)NC2=CC(OC(C)C)=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (309.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0930 mL | 15.4650 mL | 30.9301 mL | 77.3252 mL |
| 5 mM | 0.6186 mL | 3.0930 mL | 6.1860 mL | 15.4650 mL | |
| 10 mM | 0.3093 mL | 1.5465 mL | 3.0930 mL | 7.7325 mL | |
| 15 mM | 0.2062 mL | 1.0310 mL | 2.0620 mL | 5.1550 mL | |
| 20 mM | 0.1547 mL | 0.7733 mL | 1.5465 mL | 3.8663 mL | |
| 25 mM | 0.1237 mL | 0.6186 mL | 1.2372 mL | 3.0930 mL | |
| 30 mM | 0.1031 mL | 0.5155 mL | 1.0310 mL | 2.5775 mL | |
| 40 mM | 0.0773 mL | 0.3866 mL | 0.7733 mL | 1.9331 mL | |
| 50 mM | 0.0619 mL | 0.3093 mL | 0.6186 mL | 1.5465 mL | |
| 60 mM | 0.0516 mL | 0.2578 mL | 0.5155 mL | 1.2888 mL | |
| 80 mM | 0.0387 mL | 0.1933 mL | 0.3866 mL | 0.9666 mL | |
| 100 mM | 0.0309 mL | 0.1547 mL | 0.3093 mL | 0.7733 mL |
Flutolanil Related Classifications
HY-B2011 Related Classifications
Powered by Bioz
- Flutolanil
- 66332-96-5
- Environmental Pollutants
- Mitochondrial Metabolism
- Fungal
- Succinate Dehydrogenase
- succinate dehydrogenase complex
- zebrafish
- succinate-DPIP reductase
- Daphnia magna
- Rhizoctonia solani
- rat liver
- Corticium rolfsii
- succinate-Co Q reductase
- Basidiomycete fungi
- succinate-cytochrome c reductase
- Inhibitor
- inhibitor
- inhibit