BUB1B - BUB1 mitotic checkpoint serine/threonine kinase B Gene

Also Known as MVA1; SSK1; BUBR1; Bub1A; MAD3L; hBUBR1; BUB1beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 701

About BUB1B

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,161,069-40,221,123 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues, 1 paralogue and is associated with 67 phenotypes. Biased expression in testis (RPKM 16.5), bone marrow (RPKM 7.5) and 12 other tissues.

Summary

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of Cancer. [provided by RefSeq, Jul 2008]

BUB1B Products (1)

mRNA	Protein	Name
NM_001211.6	NP_001202.5	mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9660858	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in mitotic spindle assembly checkpoint signaling	IDA IDA: Inferred from direct assay	10477750	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	20220147	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20220147	GOA
colocalizes with kinetochore	IDA IDA: Inferred from direct assay	12925705	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	9660858	GOA
part of mitotic checkpoint complex	IPI IPI: Inferred from physical interaction	27509861	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	19468067	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20531406	GOA
located in spindle	IDA IDA: Inferred from direct assay	9763420	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BUB1B Protein Structure

Mad3_BUB1_I

Pkinase

0
200
400
600
800
1000
1050 a.a.

Protein Preferred Names	Protein Names
mitotic checkpoint serine/threonine-protein kinase BUB1 beta	BUB1B, mitotic checkpoint serine/threonine kinase

BUB1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	BUB1B	O60566	BUB3	Homo sapiens	O43684	Anti Tag CoIP	25852190
Intra	BUB1B	O60566	BUB3	Homo sapiens	O43684	Y2H	22000412
Intra	BUB1B	O60566	BUB3	Homo sapiens	O43684	Pull Down	25383541
Intra	BUB1B	O60566	BUB3	Homo sapiens	O43684	Anti Tag CoIP	19407811
Intra	BUB1B	O60566	BUB3	Homo sapiens	O43684	Anti Tag CoIP	35271311
Intra	BUB1B	O60566	BUB3	Homo sapiens	O43684	Anti Tag CoIP	22000412
Intra	BUB1B	O60566	BUB3	Homo sapiens	O43684	Pull Down	32707033
Intra	BUB1B	O60566	KNL1	Homo sapiens	Q8NG31-2	Y2H	22000412
Intra	BUB1B	O60566	CENPE	Homo sapiens	Q02224	Anti Tag CoIP	9763420
Intra	BUB1B	O60566	CENPE	Homo sapiens	Q02224	Y2H	9763420
Cross	BUB1B	O60566	Crebbp	Mus musculus	P45481	Anti Tag CoIP	24825348
Intra	BUB1B	O60566	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	19407811
Intra	BUB1B	O60566	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	11030144
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	25383541
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Pull Down	25383541
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	22000412
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Y2H	11030144
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	GMS	21300909
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	25852190
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Pull Down	11030144
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	TAP	20360068
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	19407811
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Pull Down	32707033
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Protein Kinase Assay	11030144
Intra	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	35271311
Intra	BUB1B	O60566	SIRT2	Homo sapiens	Q8IXJ6	Anti Tag CoIP	24825348
Intra	BUB1B	O60566	KAT2B	Homo sapiens	Q92831	IF	19407811
Intra	BUB1B	O60566	KAT2B	Homo sapiens	Q92831	Anti Bait CoIP	19407811
Intra	BUB1B	O60566	KAT2B	Homo sapiens	Q92831	Enzymatic Study	19407811
Intra	BUB1B	O60566	BUB1	Homo sapiens	O43683	Anti Tag CoIP	25852190
Intra	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	25852190
Intra	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	25383541
Intra	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	20212161
Intra	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	GMS	21300909
Intra	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Pull Down	25383541
Intra	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	22000412

Cross: Cross-species interaction Intra: Intraspecies interaction

BUB1B Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P83012	BUBR1 Antibody (YA2757)	WB, ICC/IF, IP	Human
HY-P83012A	BUBR1 Antibody (YA2757)(PBS only)	WB, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Premature Chromatid Separation Trait	PCS Total Premature Chromatid Separation Trait Chromatid Separation Trait, Premature
Mosaic Variegated Aneuploidy Syndrome 1	Mva Syndrome MVA1 Mosaic Variegated Aneuploidy Syndrome, Type 1 Mosaic Variegated Aneuploidy Syndrome Congenital Chromosomal Disease
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Rhabdomyosarcoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-172089	TG101209 analog 1	Inducer	98.27%	Unkown
HY-161865	Antitumor agent-180	Inducer	99.46%	Unkown
HY-RS01682	BUB1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19413	Bub1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25905	Bub1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BUB1B	VGNC	VGNC:70293
Mus musculus	BUB1B	MGD	MGI:1333889
Canis familiaris	BUB1B	VGNC	VGNC:38566
Felis catus	BUB1B	VGNC	VGNC:81027
Bos taurus	BUB1B	VGNC	VGNC:26605
Rattus norvegicus	BUB1B	RGD	RGD:619791
Others	BUB1B	NCBI