JNJ-2901
JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research.
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- No. CAS: 2059985-55-4
- Fòrmula: C24H24ClF3N4O3S
- Peso molecular:540.99
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
JNJ-2901 (0.005 µM-5 mM, 5 d) inhibits the growth of M. tuberculosis H37Rv-ΔcydAB in 7H9 medium (MIC50: 2.5 nM)[1].
JNJ-2901 inhibits oxygen consumption by the wild-type strain (IC50: 89 nM) and the cytochrome bd knockout strain (ΔcydAB) (IC50: 60 nM) of M. smegmatis, but has no significant effect on the cytochrome bc knockout strain (ΔqcrCAB)[1].
JNJ-2901 inhibits oxygen consumption by M. smegmatis cytochrome bcMtb-like (IC50: 17.4 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Acute/chronic mouse model infected with M. tuberculosis H37Rv-ΔcydAB, 6-8 weeks old female Balb/cBy mice[1].
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Dosage:10 mg/kg
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Administration:Subcutaneous injection (s.c.), 12 d for acute infection and 8 weeks for chronic infection
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Result:Reduced bacterial load in an acute infection model in mice (3.6-log) and in a chronic infection model (4.0-log).
Chemical Information
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No. CAS 2059985-55-4
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Peso molecular 540.99
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Fòrmula C24H24ClF3N4O3S
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SMILES
CCC1=C(N2C=C(C=CC2=N1)Cl)C(NCC3=CC=C(C=C3)C4CC5(CN(C5)S(=O)(C(F)(F)F)=O)C4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNJ-2901 Related Classifications
HY-172349 Related Classifications
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