Macrocarpal H
Based on 1 Customer Validation
Macrocarpal H is a natural compound that can be isolated from the Leaves of Eucalyptus globulus. Macrocarpal H exhibits antibacterial activity against Gram-positive cariogenic bacteria and Gram-negative periodontopathic bacteria. Macrocarpal H inhibits adherent water-insoluble glucan synthesis via glucosyltransferase. Macrocarpal H can be used for the research of caries, periodontal disease, dental caries, periodontal disorders.
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- Pureza: 73.0%
- No. CAS: 179388-53-5
- Fòrmula: C28H40O6
- Peso molecular:472.61
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Actividad biológica
Macrocarpal H (compound 7) (24-48 h) potently inhibits the growth of cariogenic bacteria including S. mutans Ingbritt, S. mutans LA7, S. sobrinus 6715, S. sobrinus B13, and A. viscosus 15987, and periodontopathic bacteria including P. gingivalis 33277, P. melaninogenica 25845, P. intermedia 25611, and C. ochracea 33596, with MIC values ranging from 0.39 to 3.13 µg/mL, and shows weaker activity against F. nucleatum 25586 with an MIC of 6.25 µg/mL[2].
Macrocarpal H (1-100 µg/mL; 16 h) strongly inhibits glucosyltransferase activity from S. sobrinus 6715, reducing adherent water-insoluble glucan synthesis by 97.6% at 100 µg/mL and 64.0% at 10 µg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 179388-53-5
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Appearance Solid
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Peso molecular 472.61
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Fòrmula C28H40O6
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Color Light yellow to yellow
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SMILES
CC(C)C[C@H](C1=C(C(C=O)=C(O)C(C=O)=C1O)O)[C@@]2([H])[C@]3([C@@](C(CC2)=C)([H])C[C@H](C(C)(O)C)CC3)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
- Macrocarpal H
- 179388-53-5
- Glucosylceramide Synthase (GCS)
- Bacterial
- periodontal disease
- Gram-negative periodontopathic bacteria
- Gram-positive cariogenic bacteria
- glucosyltransferase
- periodontopathic bacteria
- caries
- S. mutans Ingbritt
- periodontal disorders
- cariogenic bacteria
- dental caries
- Inhibitor
- inhibitor
- inhibit