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Referencia número: HY-116165

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ML-298

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Based on 1 Customer Validation

ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC₅₀ of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 96.94%
No. CAS: 1426916-02-0
Fòrmula: C₂₂H₂₃F₃N₄O₂
Peso molecular:432.44

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ML-298 Chemical Structure

No. CAS: 1426916-02-0

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Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC₅₀ of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells^[1].

Ver todos los productos específicos de isoformas Phospholipase :

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-1	IC₅₀	>20000 nM Compound: 7g, ML298, CID53393915	Inhibition of PLD1 in human Calu-1 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured after 30 mins by mass spectrometry Inhibition of PLD1 in human Calu-1 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured after 30 mins by mass spectrometry	[PMID: 23445448]
HEK293	IC₅₀	355 nM Compound: 7g, ML298, CID53393915	Inhibition of GFP-tagged PLD2 in human HEK293 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured after 30 mins by mass spectrometry Inhibition of GFP-tagged PLD2 in human HEK293 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured after 30 mins by mass spectrometry	[PMID: 23445448]

Chemical Information

No. CAS 1426916-02-0
Appearance Solid
Peso molecular 432.44
Fòrmula C₂₂H₂₃F₃N₄O₂
Color White to off-white
SMILES

FC1=CC=C(C=C1F)C(NCCN2CCC3(CC2)C(NCN3C4=CC(F)=CC=C4)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (289.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3125 mL

11.5623 mL

23.1246 mL

5 mM

0.4625 mL

2.3125 mL

4.6249 mL

10 mM

0.2312 mL

1.1562 mL

2.3125 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. O'Reilly MC, et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. J Med Chem. 2013 Mar 28;56(6):2695-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3125 mL	11.5623 mL	23.1246 mL	57.8115 mL
	5 mM	0.4625 mL	2.3125 mL	4.6249 mL	11.5623 mL
	10 mM	0.2312 mL	1.1562 mL	2.3125 mL	5.7811 mL
	15 mM	0.1542 mL	0.7708 mL	1.5416 mL	3.8541 mL
	20 mM	0.1156 mL	0.5781 mL	1.1562 mL	2.8906 mL
	25 mM	0.0925 mL	0.4625 mL	0.9250 mL	2.3125 mL
	30 mM	0.0771 mL	0.3854 mL	0.7708 mL	1.9270 mL
	40 mM	0.0578 mL	0.2891 mL	0.5781 mL	1.4453 mL
	50 mM	0.0462 mL	0.2312 mL	0.4625 mL	1.1562 mL
	60 mM	0.0385 mL	0.1927 mL	0.3854 mL	0.9635 mL
	80 mM	0.0289 mL	0.1445 mL	0.2891 mL	0.7226 mL
	100 mM	0.0231 mL	0.1156 mL	0.2312 mL	0.5781 mL

Keywords

100 mg

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Actividad biológica
- Descripciòn
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias

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ML-298

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Lipid Metabolism Compound Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas Phospholipase

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

ML-298

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Lipid Metabolism Compound Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas Phospholipase

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

ML-298 Related Classifications

HY-116165 Related Classifications