MPC-IN-1
Based on 1 Customer Validation
MPC-IN-1 (compound 4i) is a cyanocinnamate-based, mitochondrial pyruvate transporter (MPC) inhibitor, and is a derivative of UK-5099 (HY-15475). MPC inhibitors promote the development of hair follicle stem cells without affecting normal cells. MPC-IN-1 promotes cellular lactate production and promotes significant hair growth in mice, and has the potential to be used to inhibit hair loss.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.55%
- Fòrmula: C18H13N3O2
- Peso molecular:303.31
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Metabolism/Protease Compound Library
HY-L012
-
Stem Cell Signaling Compound Library
HY-L017
-
Anti-Aging Compound Library
HY-L034
-
Reprogramming Compound Library
HY-L039
-
Glutamine Metabolism Compound Library
HY-L064
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Anti-Parkinson's Disease Compound Library
HY-L085
-
Neurodegenerative Disease-related Compound Library
HY-L086
-
Mitochondria-Targeted Compound Library
HY-L089
-
Glucose Metabolism Compound Library
HY-L092
-
Cuproptosis Compound Library
HY-L133
-
Cancer Stem Cells Compound Library
HY-L135
-
Mitochondrial Protection Compound Library
HY-L144
-
Metabolic Enzyme Compound Library
HY-L146
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
Actividad biológica
Mitochondrial pyruvate carrier (MPC)[1]
Chemical Information
-
Appearance Solid
-
Peso molecular 303.31
-
Fòrmula C18H13N3O2
-
Color Light yellow to yellow
-
SMILES
OC(/C(C#N)=C/C1=CN(CC2=CC=CC=N2)C3=CC=CC=C31)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (329.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
-
Ficha de datos (277 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2970 mL | 16.4848 mL | 32.9696 mL | 82.4239 mL |
| 5 mM | 0.6594 mL | 3.2970 mL | 6.5939 mL | 16.4848 mL | |
| 10 mM | 0.3297 mL | 1.6485 mL | 3.2970 mL | 8.2424 mL | |
| 15 mM | 0.2198 mL | 1.0990 mL | 2.1980 mL | 5.4949 mL | |
| 20 mM | 0.1648 mL | 0.8242 mL | 1.6485 mL | 4.1212 mL | |
| 25 mM | 0.1319 mL | 0.6594 mL | 1.3188 mL | 3.2970 mL | |
| 30 mM | 0.1099 mL | 0.5495 mL | 1.0990 mL | 2.7475 mL | |
| 40 mM | 0.0824 mL | 0.4121 mL | 0.8242 mL | 2.0606 mL | |
| 50 mM | 0.0659 mL | 0.3297 mL | 0.6594 mL | 1.6485 mL | |
| 60 mM | 0.0549 mL | 0.2747 mL | 0.5495 mL | 1.3737 mL | |
| 80 mM | 0.0412 mL | 0.2061 mL | 0.4121 mL | 1.0303 mL | |
| 100 mM | 0.0330 mL | 0.1648 mL | 0.3297 mL | 0.8242 mL |
MPC-IN-1 Related Classifications
HY-162831 Related Classifications
Powered by Bioz