NNMT-IN-8
NNMT-IN-8 is a non-SAM-mimicking bisubstrate inhibitor and a selective methyltransferase NNMT inhibitor, with IC50 values of 0.0084 μM and 0.0085 μM against human NNMT, and an IC50 of 0.0072 μM against mouse NNMT. NNMT-IN-8 exhibits prominent renal distribution characteristics and moderate bioavailability in rodents. NNMT-IN-8 dose-dependently inhibits renal NNMT in renal fibrosis models, thereby exerting antifibrotic effects. NNMT-IN-8 can be used to investigate the mechanisms of renal fibrosis.
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- No. CAS: 3124204-81-2
- Fòrmula: C23H25FN4O2S
- Peso molecular:440.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
NNMT-IN-8 (compound 16) inhibits NNMT activity in cells overexpressing human NNMT, with an IC50 of 0.25 μM[1].
NNMT-IN-8 exhibits metabolic stability in human liver microsomes, rat liver microsomes, and mouse liver microsomes, with 79%, 34%, and 23% remaining after 30 min of incubation[1].
NNMT-IN-8 (3 μM) inhibits hERG current by 15%, indicating a low risk of cardiotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3124204-81-2
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Peso molecular 440.53
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Fòrmula C23H25FN4O2S
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SMILES
O=C1SC2=C(NCC34CCC(CC3)(C4)NCC5=C(F)C(C(N)=O)=CC=C5)C=CC=C2N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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