Z226407860
Z226407860 is a RING-box protein 1 (RBX1) inhibitor. Z226407860 reduces house dust mite-induced airway epithelial injury and ROS accumulation by inhibiting RBX1. Z226407860 can be used for the research of asthma.
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- No. CAS: 2419496-02-7
- Fòrmula: C28H36N4O5S
- Peso molecular:540.67
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Z226407860 (5 μM) potently inhibits the expression of RBX1 mRNA and protein in normal HBE cells, and suppresses HDM-induced overexpression of RBX1 protein in HBE cells[1].
Z226407860 (5 μM) alleviates HDM-induced epithelial barrier dysfunction in HBE cells by restoring the levels of Occludin and E-cadherin, and reduces the accumulation of reactive oxygen species (ROS) in cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2419496-02-7
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Peso molecular 540.67
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Fòrmula C28H36N4O5S
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SMILES
OC1=CC=C(CCC2CCN(C(CCC3=NC(C=C(S(N4CCOCC4)(=O)=O)C=C5)=C5N3C)=O)CC2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z226407860 Related Classifications
HY-182063 Related Classifications
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