PRDX3 - peroxiredoxin 3 Gene

Also Known as AOP1; MER5; AOP-1; PPPCD; SP-22; HBC189; SCAR32; PRO1748; prx-III

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10935

About PRDX3

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,167,720-119,178,812 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 195.5), kidney (RPKM 144.1) and 25 other tissues.

Summary

This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue Bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate Cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

PRDX3 Products (2)

mRNA Protein Name
NM_001302272.2 NP_001289201.1 thioredoxin-dependent peroxide reductase, mitochondrial isoform c precursor
NM_006793.5 NP_006784.1 thioredoxin-dependent peroxide reductase, mitochondrial isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
18262354 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12492477 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21850687 GOA
enables thioredoxin peroxidase activity IDA
IDA: Inferred from direct assay
21850687 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
21850687 GOA
involved in cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
18262354 GOA
acts upstream of or within hydrogen peroxide catabolic process IDA
IDA: Inferred from direct assay
7733872 GOA
involved in hydrogen peroxide catabolic process IMP
IMP: Inferred from mutant phenotype
18195003 GOA
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
12011429 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
21850687 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18262354 GOA
involved in negative regulation of kinase activity IDA
IDA: Inferred from direct assay
18205602 GOA
involved in peptidyl-cysteine oxidation IDA
IDA: Inferred from direct assay
21850687 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
12492477 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12011429 GOA
involved in regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
12011429 GOA
involved in response to hydrogen peroxide IDA
IDA: Inferred from direct assay
17893648 GOA
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
18195003 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18205602 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21850687 GOA
located in early endosome IDA
IDA: Inferred from direct assay
15750338 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
17893648 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20873783 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX3 Protein Structure

AhpC-TSA

AhpC-TSA: AhpC/TSA family (65 - 197)

1-cysPrx_C

1-cysPrx_C: C-terminal domain of 1-Cys peroxiredoxin (218 - 253)

  • 0
  • 100
  • 200
  • 256 a.a.
Protein Preferred Names Protein Names

thioredoxin-dependent peroxide reductase, mitochondrial

  • antioxidant protein 1

PRDX3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRDX3 P30048 ZNF77 Homo sapiens Q15935
Validated Y2H
32296183
Intra
PRDX3 P30048 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
21850687
Intra
PRDX3 P30048 LRRK2 Homo sapiens Q5S007
Anti Bait CoIP
21850687
Intra
PRDX3 P30048 LRRK2 Homo sapiens Q5S007
Protein Kinase Assay
21850687
Intra
PRDX3 P30048 LRRK2 Homo sapiens Q5S007
Confocal
24459295
Intra
PRDX3 P30048 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
Intra
PRDX3 P30048 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
29892012
Intra
PRDX3 P30048 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
31515488
Intra
PRDX3 P30048 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRDX3 Proteins

Cat. No. Product Name Accession Purity
HY-P71147 PRDX3 Protein, Human P30048-1 (P63-Q256) ≥ 95%, as determined by reducing SDS-PAGE.

PRDX3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81066 PRDX3 Antibody (YA909) WB, ICC/IF, IHC-P, FC, IP Human

Related Diseases

Diseases Alias
Spinocerebellar Ataxia, Autosomal Recessive 32

  • SCAR32

  • Spinocerebellar Ataxia, Autosomal Recessive, 32
Corneal Dystrophy, Punctiform And Polychromatic Pre-Descemet

  • PPPCD
Autosomal Recessive Cerebellar Ataxia

  • Arca
Fuchs' Endothelial Dystrophy

  • Fuchs Endothelial Corneal Dystrophy

  • Fuchs Endothelial Dystrophy

  • Fuchs Dystrophy

  • Fced

  • Fuchs' Corneal Dystrophy

  • Fuchs' Endothelial Corneal Dystrophy

  • Fuchs Atrophy

  • Fuchs Corneal Dystrophy

  • Endoepithelial Corneal Dystrophy

  • Fecd

  • Late Hereditary Endothelial Dystrophy

  • Corneal Dystrophy, Fuchs Endothelial

  • Dystrophy, Corneal, Fuchs Endothelial

  • Corneal Dystrophy, Fuchs' Endothelial, 1
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Ocular Cancer

  • Eye Neoplasm

  • Eye Carcinoma

  • Eye Cancer

  • Eye Neoplasms

  • Malignant Eye Neoplasm

  • Neoplasm Of Eye

  • Neoplasm Of Eye Proper

  • Ocular Tumor

  • Carcinoma Of Eye

  • Ocular Carcinoma

  • Malignant Tumor Of Eye
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10132 PRDX3(103-112), human / Unkown
HY-P10133 PRDX3(103-112) SO3 modified, human / Unkown
HY-RS11076 PRDX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17991 Prdx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24462 Prdx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRDX3 MGD MGI:88034
Felis catus PRDX3 VGNC VGNC:69038
Bos taurus PRDX3 VGNC VGNC:33301
Macaca mulatta PRDX3 VGNC VGNC:76394
Rattus norvegicus PRDX3 RGD RGD:620040
Others PRDX3 NCBI