ZNF77 - zinc finger protein 77 Gene

Also Known as pT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58492

About ZNF77

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,933,218-2,950,625 (from NCBI)

This gene has 2 transcripts (splice variants), 154 orthologues and 62 paralogues. Ubiquitous expression in thyroid (RPKM 1.9), testis (RPKM 1.7) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF77 Products (1)

mRNA Protein Name
NM_021217.3 NP_067040.1 zinc finger protein 77

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF77 Protein Structure

KRAB

KRAB: KRAB box (4 - 44)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (212 - 235)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (255 - 278)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (283 - 306)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (311 - 334)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (338 - 362)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (366 - 390)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (395 - 418)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (422 - 446)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (450 - 475)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (479 - 502)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (506 - 530)

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  • 200
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  • 400
  • 500
  • 545 a.a.
Protein Preferred Names Protein Names

zinc finger protein 77

  • ZNFpT1

ZNF77 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF77 Q15935 MBD3L1 Homo sapiens Q8WWY6
Y2H Prey Pooling
32296183
Intra
ZNF77 Q15935 MBD3L1 Homo sapiens Q8WWY6
Validated Y2H
32296183
Intra
ZNF77 Q15935 MBD3L1 Homo sapiens Q8WWY6
Y2H Array
32296183
Intra
ZNF77 Q15935 RSPO4 Homo sapiens Q2I0M5
Y2H Prey Pooling
32296183
Intra
ZNF77 Q15935 RSPO4 Homo sapiens Q2I0M5
Y2H Array
32296183
Intra
ZNF77 Q15935 RSPO4 Homo sapiens Q2I0M5
Validated Y2H
32296183
Intra
ZNF77 Q15935 NICN1 Homo sapiens Q9BSH3
Y2H Array
32296183
Intra
ZNF77 Q15935 NICN1 Homo sapiens Q9BSH3
Validated Y2H
32296183
Intra
ZNF77 Q15935 NICN1 Homo sapiens Q9BSH3
Y2H Prey Pooling
32296183
Intra
ZNF77 Q15935 FTO Homo sapiens Q9C0B1-2
Validated Y2H
32296183
Intra
ZNF77 Q15935 FTO Homo sapiens Q9C0B1-2
Y2H Array
32296183
Intra
ZNF77 Q15935 FTO Homo sapiens Q9C0B1-2
Y2H Prey Pooling
32296183
Intra
ZNF77 Q15935 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra
ZNF77 Q15935 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra
ZNF77 Q15935 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra
ZNF77 Q15935 PRDX3 Homo sapiens P30048
Y2H Prey Pooling
32296183
Intra
ZNF77 Q15935 PRDX3 Homo sapiens P30048
Y2H Array
32296183
Intra
ZNF77 Q15935 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32296183
Intra
ZNF77 Q15935 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
Intra
ZNF77 Q15935 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tuberculous Epididymitis

  • Tuberculosis Of Epididymis
Anorectal Stricture

  • Stenosis Of Rectum And Anus

  • Anorectal Malformations
Bone Squamous Cell Carcinoma
Bladder Lateral Wall Cancer

  • Lateral Wall Of Bladder

  • Malignant Neoplasm Of Lateral Wall Of Urinary Bladder
Essential Thrombocythemia

  • Essential Thrombocytosis

  • Familial Thrombocytosis

  • Hemorrhagic Thrombocythemia

  • Hereditary Thrombocythemia

  • Primary Thrombocytosis

  • Idiopathic Thrombocythemia

  • Primary Thrombocythemia

  • Thrombocythemia, Essential

  • Essential Thrombocythaemia

  • Et

  • Familial Thrombocythemia

  • Thrombocythemia Essential
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16175 ZNF77 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZNF77 RGD RGD:6497573
Macaca mulatta ZNF77 VGNC VGNC:78906
Others ZNF77 NCBI