CTRC - chymotrypsin C Gene

Also Known as CLCR; ELA4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11330

About CTRC

Cytogenetic location: 1p36.21 Genomic coordinates (GRCh38): 1:15,438,443-15,449,242 (from NCBI)

This gene has 4 transcripts (splice variants), 102 orthologues, 2 paralogues and is associated with 4 phenotypes. Restricted expression toward pancreas (RPKM 2413.6).

Summary

This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

CTRC Products (1)

mRNA Protein Name
NM_007272.3 NP_009203.2 chymotrypsin-C preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IDA
IDA: Inferred from direct assay
8635596 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
8635596 GOA
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
8635596 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTRC Protein Structure

Trypsin

Trypsin: Trypsin (30 - 262)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

chymotrypsin-C

  • caldecrin

CTRC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTRC Q99895 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
CTRC Q99895 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
CTRC Q99895 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra
CTRC Q99895 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
CTRC Q99895 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra
CTRC Q99895 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
CTRC Q99895 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 VGLL3 Homo sapiens A8MV65-2
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 VGLL3 Homo sapiens A8MV65-2
Y2H Array
32296183
Intra
CTRC Q99895 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
CTRC Q99895 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
CTRC Q99895 SUMF1 Homo sapiens Q8NBK3
Anti Tag CoIP
33961781
Intra
CTRC Q99895 SUMF1 Homo sapiens Q8NBK3
Anti Tag CoIP
28514442
Intra
CTRC Q99895 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
CTRC Q99895 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 GIPC2 Homo sapiens Q8TF65
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 GIPC2 Homo sapiens Q8TF65
Y2H Array
32296183
Intra
CTRC Q99895 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
CTRC Q99895 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 SPMIP9 Homo sapiens Q96LM6
Y2H Array
32296183
Intra
CTRC Q99895 SPMIP9 Homo sapiens Q96LM6
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra
CTRC Q99895 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra
CTRC Q99895 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CTRC Proteins

Cat. No. Product Name Accession Purity
HY-P70098 CTRC Protein, Human (HEK293, His) Q99895 (C17-L268) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pancreatitis, Hereditary

  • Hereditary Pancreatitis

  • Chronic Pancreatitis

  • Hereditary Chronic Pancreatitis

  • Hp

  • Pancreatitis, Chronic, Susceptibility To

  • PCTT

  • Hpc

  • Pancreatitis, Chronic

  • Pancreatitis, Chronic, Protection Against

  • Autosomal Dominant Hereditary Pancreatitis

  • Familial Pancreatitis

  • Cp

  • Pancreatitis Hereditary
Prss1-Related Hereditary Pancreatitis
Tropical Calcific Pancreatitis

  • Tropical Pancreatitis

  • TCP

  • Fibrocalculous Pancreatic Diabetes

  • Tropical Calcific Chronic Pancreatitis

  • Fibrocalculous Pancreatic Diabetes, Susceptibility To

  • Tcp - [Tropical Chronic Pancreatitis]
Pancreatitis

  • Mumps Pancreatitis
Acute Pancreatitis

  • Pancreatitis

  • Pancreatitis, Acute Necrotizing

  • Pancreatitis Nos

  • Acute Pancreas Inflammation
Pancreas, Annular

  • Annular Pancreas

  • Pancreas Annulare

  • Congenital Annular Pancreas
Alcoholic Pancreatitis

  • Pancreatitis, Alcoholic

  • Pancreatitis Alcoholic
Bile Duct Cysts

  • Choledochal Cyst

  • Choledochal Cysts

  • Choledochocele

  • Biliary Cyst

  • Congenital Choledochal Cyst

  • Bile Duct Cyst

  • Congenital Cystic Dilatation Of The Biliary Tract

  • Congenital Bile Duct Dilatation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03319 CTRC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18471 Ctrc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24952 Ctrc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CTRC VGNC VGNC:27811
Felis catus CTRC VGNC VGNC:61263
Rattus norvegicus CTRC RGD RGD:1308379
Mus musculus CTRC MGD MGI:1923951
Others CTRC NCBI