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Gdf11 - growth differentiation factor 11 Gene

Also Known as Bmp11; BMP-11

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14561

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and Other organ systems, and may regulate aging. Mice lacking a functional copy of this gene exhibit impaired anteroposterior patterning and Other developmental defects. [provided by RefSeq, Aug 2016]

Gdf11 Products (1)

mRNA	Protein	Name
NM_010272.2	NP_034402.1	growth/differentiation factor 11 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16845371	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of amacrine cell differentiation	IDA IDA: Inferred from direct assay	15976303	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	15548585	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	10391213	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	15976303	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15548585	MGI
acts upstream of or within metanephros development	IDA IDA: Inferred from direct assay	12729564	MGI
acts upstream of or within negative regulation of amacrine cell differentiation	IDA IDA: Inferred from direct assay	15976303	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15548585	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	15976303	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	15976303	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	15548585	MGI
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	16845371	MGI
acts upstream of or within roof of mouth development	IGI IGI: Inferred from genetic interaction	24019467	MGI
acts upstream of or within skeletal system development	IGI IGI: Inferred from genetic interaction	24019467	MGI
acts upstream of or within spinal cord anterior/posterior patterning	IMP IMP: Inferred from mutant phenotype	16790475	MGI
acts upstream of or within type B pancreatic cell maturation	IMP IMP: Inferred from mutant phenotype	15548585	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	12729564	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12729564	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
growth/differentiation factor 11	GDF-11 bone morphogenetic protein 11

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99720	Luspatercept	Inhibitor	98.92%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99590A	Sotatercept (mIgG2a)	Inhibitor	99.93%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05351	GDF11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18279	Gdf11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24757	Gdf11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gdf11	NCBI	NCBI:10220