AGO3 - argonaute RISC catalytic component 3 Gene

Homo sapiens

Also known as EIF2C3

Gene ID: 192669 | Gene type: protein coding

About AGO3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,930,718-36,072,500 (from NCBI)

This gene has 7 transcripts (splice variants), 277 orthologues and 3 paralogues. Ubiquitous expression in skin (RPKM 1.4), testis (RPKM 1.4) and 25 other tissues.

Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

AGO3 Products(2)

mRNA	Protein	Name
NM_024852.4	NP_079128.2	protein argonaute-3 isoform a
NM_177422.3	NP_803171.1	protein argonaute-3 isoform b

AGO3 Protein Structure

ArgoL1

PAZ

Piwi

0
200
400
600
800
860 a.a.

Protein Preferred Names

Protein Names

protein argonaute-3

argonaute 3, RISC catalytic component

Recombinant AGO3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74422	AGO3 Protein, Human (sf9, His)	Q9H9G7 (M1-A860)	≥95%

Related Diseases

Diseases

Alias

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00454	AGO3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AGO3	VGNC	VGNC:107484
Rattus norvegicus	AGO3	RGD	RGD:1309163
Macaca mulatta	AGO3	VGNC	VGNC:99838
Mus musculus	AGO3	MGD	MGI:2446634
Canis familiaris	AGO3	VGNC	VGNC:37708
Others	AGO3	NCBI