Glis1 - GLIS family zinc finger 1 Gene

Also Known as Gli5; Gli6; GliH1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230587

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including fat cell differentiation; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; sensory organ; and skin. Orthologous to human GLIS1 (GLIS family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Glis1 Products (1)

mRNA Protein Name
NM_147221.2 NP_671754.2 zinc finger protein GLIS1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12042312 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12042312 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12042312 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12042312 MGI
Biological Process GO Annotation Evidence References Source
involved in fat cell differentiation IMP
IMP: Inferred from mutant phenotype
30544251 MGI
involved in negative regulation of cell fate commitment IMP
IMP: Inferred from mutant phenotype
30544251 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12042312 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12042312 MGI
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
30544251 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12042312 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12042312 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12385751 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12042312 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein GLIS1

  • GLI-Kruppel family member GLI6

  • GLI-similar 1

  • Glis1 Kruppel-like zinc finger protein

  • gli homologous protein 1

  • zinc finger transcription factor Gli5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13901 GANT 61 99.80% Unkown
HY-P4860 Adropin (34-76) (human, mouse, rat) 98.23% Unkown
HY-13282 GANT 58 Antagonist 99.37% Unkown
HY-N2112 Glaucocalyxin A 99.88% Unkown
HY-18366A RU-SKI 43 hydrochloride Inhibitor 98.81% Unkown
HY-122590 Glabrescione B Inhibitor 98.08% Unkown
HY-107551 Hh Pathway-IN-1 99.06% Unkown
HY-107408 SANT 2 Antagonist 99.41% Unkown
HY-W111144 T-1330 Inhibitor / Unkown
HY-18366 RU-SKI 43 Inhibitor / Unkown
HY-RS05472 GLI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-137567 Prostaglandin E1 ethanolamide Activator / Unkown
HY-143400 HSP70-IN-3 Inhibitor / Unkown
HY-147670 TPB15 / Unkown
HY-159893 SMO-IN-5 / Unkown
HY-161459 GLI1-IN-1 / Unkown
HY-162273 Antibacterial agent 189 Inhibitor / Unkown
HY-176056 Hedgehog IN-9 / Unkown
HY-182641 SAG analog (cis-isomer) Activator / Unkown
HY-183335 SMO-IN-6 / Unkown
HY-N8270 Physalin H Inhibitor / Unkown
HY-N9684 Degalactotigonin / Unkown
HY-RS05473 Gli1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05474 Gli1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05480 GLIS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122017 Methoxy-SANT-2 Antagonist / Unkown
HY-172449 GLI1-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glis1 NCBI NCBI:148979