FOLR3 - folate receptor gamma Gene

Also Known as FR-G; FRgamma; FR-gamma; gamma-hFR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2352

About FOLR3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,135,725-72,139,892 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 27.0), appendix (RPKM 4.9) and 3 other tissues.

Summary

This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

FOLR3 Products (2)

mRNA Protein Name
NM_000804.4 NP_000795.2 folate receptor gamma isoform 1 precursor
NM_001412270.1 NP_001399199.1 folate receptor gamma isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOLR3 Protein Structure

Folate_rec

Folate_rec: Folate receptor family (146 - 253)

  • 0
  • 100
  • 200
  • 287 a.a.
Protein Preferred Names Protein Names

folate receptor gamma

  • folate receptor 3 (gamma)

FOLR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
FOLR3 P41439 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
FOLR3 P41439 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FOLR3 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P78766 FOLR3 Protein, Human (HEK293, His) P41439 (Q23-S245) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Primary Peritoneal Carcinoma

  • Serous Surface Papillary Carcinoma

  • Eoppc

  • Extra-Ovarian Primary Peritoneal Carcinoma

  • Ppc

  • Primary Peritoneal Serous Carcinoma

  • Primary Peritoneal Serous Adenocarcinoma
Choriocarcinoma Of The Testis

  • Testicular Choriocarcinoma
Subacute Leukemia
Folate Malabsorption, Hereditary

  • Hereditary Folate Malabsorption

  • Congenital Defect Of Folate Absorption

  • Congenital Folate Malabsorption

  • Folic Acid Transport Defect

  • HFM
Exudative Vitreoretinopathy 3

  • EVR3
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05031 FOLR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P990941 Rinatabart 99.47% Unkown
HY-P992004 KHK2805 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FOLR3 MGD MGI:95569
Others FOLR3 NCBI